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    Klra7 killer cell lectin-like receptor, subfamily A, member 7 [ Mus musculus (house mouse) ]

    Gene ID: 16638, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Klra7provided by MGI
    Official Full Name
    killer cell lectin-like receptor, subfamily A, member 7provided by MGI
    Primary source
    MGI:MGI:101901
    See related
    Ensembl:ENSMUSG00000067599 AllianceGenome:MGI:101901
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LGL-1; Ly49g; Ly49g1; Ly49g2; Ly49G.4; Ly-49G.1; Ly-49G.2; Ly-49G.3
    Summary
    Predicted to enable signaling receptor activity. Predicted to be involved in regulation of signal transduction. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Klra7 in Genome Data Viewer
    Location:
    6 F3; 6 63.44 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (130195568..130210285, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (130218605..130233322, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23552 Neighboring gene killer cell lectin-like receptor subfamily A, member 9 Neighboring gene predicted gene, 52487 Neighboring gene killer cell lectin-like receptor subfamily A, member 10 Neighboring gene killer cell lectin-like receptor subfamily A, member 13, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LGL-1: a potential triggering molecule on murine NK cells. Mason LH, et al. J Leukoc Biol, 1994 Mar. PMID 7509843
    2. Allelic variation in the ectodomain of the inhibitory Ly-49G2 receptor alters its specificity for allogeneic and xenogeneic ligands. Silver ET, et al. J Immunol, 2002 Nov 1. PMID 12391184
    3. MHC class I D(k) expression in hematopoietic and nonhematopoietic cells confers natural killer cell resistance to murine cytomegalovirus. Xie X, et al. Proc Natl Acad Sci U S A, 2010 May 11. PMID 20421478, Free PMC Article
    4. Cloning and functional characteristics of murine large granular lymphocyte-1: a member of the Ly-49 gene family (Ly-49G2). Mason LH, et al. J Exp Med, 1995 Aug 1. PMID 7629495, Free PMC Article
    5. Expression of different members of the Ly-49 gene family defines distinct natural killer cell subsets and cell adhesion properties. Brennan J, et al. J Exp Med, 1994 Dec 1. PMID 7964501, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ectodomain of inhibitory Ly49G of the BALB/c mouse strain is highly similar to the Ly49W activating receptor in the nonobese diabetic (NOD) mouse.
      Title: The activating Ly49W and inhibitory Ly49G NK cell receptors display similar affinities for identical MHC class I ligands.
    2. High levels of Ly49G2 have a dominant inhibitory effect on Ly49D expressed at low levels on immature bone marrow and mature B cells, resulting in inhibition of interferon-gamma secretion.
      Title: Tight regulation of IFN-gamma transcription and secretion in immature and mature B cells by the inhibitory MHC class I receptor, Ly49G2.
    3. Allelic variation in Ly-49G2 extracellular domains has functional significance by altering Ly-49 receptor specificity for class I MHC and xenogeneic ligands.
      Title: Allelic variation in the ectodomain of the inhibitory Ly-49G2 receptor alters its specificity for allogeneic and xenogeneic ligands.
    4. Glycosylation of Ly-49G2 at amino acid residues NTT221-23 reduces receptor binding to H-2Dd tetramers and may represent a mechanism by which natural killer cells regulate affinity for host class I ligands.
      Title: Receptor glycosylation regulates Ly-49 binding to MHC class I.
    5. The repertoire of inhibitory Ly49 receptors may be formed under the influenced of Fyn-dependent NK cell activation as well as the respective MHC class I environment.
      Title: A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123448, MGC161317

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    killer cell lectin-like receptor 7
    Names
    T-cell surface glycoprotein Ly-49G
    ly-49g
    lymphocyte antigen 49g

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110323.1 → NP_001103793.1  killer cell lectin-like receptor 7 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC161448, U10093
      Consensus CDS
      CCDS51928.1
      UniProtKB/Swiss-Prot
      Q60654, Q60655, Q60656, Q60683
      UniProtKB/TrEMBL
      F8WJ94
      Related
      ENSMUSP00000032286.7, ENSMUST00000032286.7
      Conserved Domains (2) summary
      cd03593
      Location:158 → 273
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:40 → 171
      Ly49; Ly49-like protein, N-terminal region

    2. NM_014194.5 → NP_055009.5  killer cell lectin-like receptor 7 isoform 2

      See identical proteins and their annotated locations for NP_055009.5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' and 3' UTR and lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      U10094
      Consensus CDS
      CCDS39668.1
      UniProtKB/TrEMBL
      Q9EP76
      Related
      ENSMUSP00000037917.8, ENSMUST00000049304.14
      Conserved Domains (2) summary
      cd03593
      Location:145 → 260
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:40 → 158
      Ly49; Ly49-like protein, N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      130195568..130210285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60654.1 GenPept UniProtKB/Swiss-Prot:Q60654

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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