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    rga-2 Rho GTPase-activating protein 20 [ Caenorhabditis elegans ]

    Gene ID: 173079, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rga-2
    Official Full Name
    Rho GTPase-activating protein 20
    Primary source
    WormBase:WBGene00013135
    Locus tag
    CELE_Y53C10A.4
    See related
    AllianceGenome:WB:WBGene00013135
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Is expressed in rectum; socket cell; uterus; and vulva. Orthologous to several human genes including ARHGAP20 (Rho GTPase activating protein 20). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See rga-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (11979401..11985619)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Lipid desaturase domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. actomyosin-generated tension must be moderated in two out of the three sets of epidermal cells surrounding the C. elegans embryo to achieve morphogenesis
      Title: The RhoGAP RGA-2 and LET-502/ROCK achieve a balance of actomyosin-dependent forces in C. elegans epidermis to control morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rho GTPase-activating protein 20
    NP_493035.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      11979401..11985619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060634.7 → NP_493035.1  Rho GTPase-activating protein 20 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493035.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XW53
      Conserved Domains (2) summary
      cd04402
      Location:253 → 437
      RhoGAP_ARHGAP20; RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by ...
      cl17171
      Location:25 → 111
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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