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    hpo-13 Non-lysosomal glucosylceramidase [ Caenorhabditis elegans ]

    Gene ID: 173305, updated on 18-Sep-2024

    Summary

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    Official Symbol
    hpo-13
    Official Full Name
    Non-lysosomal glucosylceramidase
    Primary source
    WormBase:WBGene00013670
    Locus tag
    CELE_Y105E8A.10
    See related
    AllianceGenome:WB:WBGene00013670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable beta-glucosidase activity. Predicted to be involved in carbohydrate metabolic process and glucosylceramide catabolic process. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 46. Orthologous to human GBA2 (glucosylceramidase beta 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See hpo-13 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (14418197..14431868)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene AP-1 complex subunit gamma Neighboring gene BolA-like protein 3 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables beta-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucosylceramidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucosylceramide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Non-lysosomal glucosylceramidase
    NP_001021681.1
    • Confirmed by transcript evidence
    NP_001359639.1
    • Confirmed by transcript evidence
    NP_001379302.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14418197..14431868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392976.1 → NP_001379302.1  Non-lysosomal glucosylceramidase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WQB2
      Conserved Domains (2) summary
      pfam04685
      Location:522 → 888
      DUF608; Glycosyl-hydrolase family 116, catalytic region
      pfam12215
      Location:149 → 457
      Glyco_hydr_116N; beta-glucosidase 2, glycosyl-hydrolase family 116 N-term

    2. NM_001373663.2 → NP_001359639.1  Non-lysosomal glucosylceramidase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6EUT3
      Conserved Domains (2) summary
      pfam04685
      Location:485 → 851
      DUF608; Glycosyl-hydrolase family 116, catalytic region
      pfam12215
      Location:112 → 415
      Glyco_hydr_116N; beta-glucosidase 2, glycosyl-hydrolase family 116 N-term

    3. NM_001026510.4 → NP_001021681.1  Non-lysosomal glucosylceramidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021681.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6EUT4
      Conserved Domains (2) summary
      pfam04685
      Location:493 → 861
      DUF608; Protein of unknown function, DUF608
      pfam12215
      Location:120 → 428
      GBA2_N; beta-Glucocerebrosidase 2 N terminal
    Nucleotide Protein
    Heading Accession and Version

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