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    nfyb-1 Nuclear transcription factor Y subunit nfyb-1 [ Caenorhabditis elegans ]

    Gene ID: 173435, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nfyb-1
    Official Full Name
    Nuclear transcription factor Y subunit nfyb-1
    Primary source
    WormBase:WBGene00021132
    Locus tag
    CELE_W10D9.4
    See related
    AllianceGenome:WB:WBGene00021132
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA-binding transcription repressor activity. Involved in negative regulation of transcription by RNA polymerase II and tissue development. Located in cytoplasm and perikaryon. Is expressed in several structures, including excretory cell; germ line; intestine; neurons; and oocyte. Orthologous to human NFYB (nuclear transcription factor Y subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See nfyb-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (461667..467365, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Mediator of RNA polymerase II transcription subunit 21 Neighboring gene MKRN2 opposite strand protein-like C-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Mitochondrial import receptor subunit TOM22 homolog Neighboring gene 26S rRNA (cytosine-C(5))-methyltransferase nsun-1 Neighboring gene G_PROTEIN_RECEP_F2_4 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of the CCAAT-binding factor NF-Y in Caenorhabditis elegans. Franchini A, et al. J Mol Histol, 2005 Feb. PMID 15704008
    2. The NF-Y complex negatively regulates Caenorhabditis elegans tbx-2 expression. Milton AC, et al. Dev Biol, 2013 Oct 1. PMID 23933492, Free PMC Article
    3. The CCAAT-box transcription factor, NF-Y complex, mediates the specification of the IL1 neurons in C. elegans. Heo W, et al. BMB Rep, 2023 Mar. PMID 36330709, Free PMC Article
    4. Nfya-1 functions as a substrate of ERK-MAP kinase during Caenorhabditis elegans vulval development. Aklilu S, et al. Cells Dev, 2022 Mar. PMID 34838796, Free PMC Article
    5. Caenorhabditis elegans TBX-2 Directly Regulates Its Own Expression in a Negative Autoregulatory Loop. Milton AC, et al. G3 (Bethesda), 2015 Apr 14. PMID 25873636, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results identify NF-Y as an important regulator of tbx-2 function in vivo.
      Title: The NF-Y complex negatively regulates Caenorhabditis elegans tbx-2 expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CCAAT-binding factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCAAT-binding factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear transcription factor Y subunit nfyb-1
    NP_001303801.1
    • Confirmed by transcript evidence
    NP_493740.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      461667..467365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061339.7 → NP_493740.1  Nuclear transcription factor Y subunit nfyb-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493740.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0M7RFF4, O17286
      Conserved Domains (1) summary
      pfam00808
      Location:64 → 129
      CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone

    2. NM_001316872.3 → NP_001303801.1  Nuclear transcription factor Y subunit nfyb-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0M7RFF4
      Conserved Domains (1) summary
      pfam00808
      Location:1 → 55
      CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O17286.1

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