ras-1 R-RAS related [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: ras-1
Official Full Name: R-RAS related
Primary source: WormBase:WBGene00004310
Locus tag: CELE_C44C11.1
See related: AllianceGenome:WB:WBGene00004310
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in parturition and vulval development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Used to study RASopathy. Human ortholog(s) of this gene implicated in Noonan syndrome 12. Orthologous to human RRAS (RAS related) and RRAS2 (RAS related 2). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See ras-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (12345285..12352243, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

STS2-31 (e-PCR)
- UniSTS:241929

C44C11.1 (e-PCR)
- UniSTS:321672

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in parturition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vulval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: R-RAS related

NP_496623.1

Product from WormBase gene class ras;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

12345285..12352243 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064222.7 → NP_496623.1 R-RAS related [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496623.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EBK8

Conserved Domains (2) summary

cd04145
Location:30 → 179

M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

smart00010
Location:30 → 181

small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily