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    stt-3 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt-3 [ Caenorhabditis elegans ]

    Gene ID: 175886, updated on 2-Nov-2024

    Summary

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    Official Symbol
    stt-3
    Official Full Name
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt-3
    Primary source
    WormBase:WBGene00020437
    Locus tag
    CELE_T12A2.2
    See related
    AllianceGenome:WB:WBGene00020437
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in post-translational protein modification and protein N-linked glycosylation via asparagine. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ix. Orthologous to human STT3B (STT3 oligosaccharyltransferase complex catalytic subunit B). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See stt-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (6248642..6251607)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene GEN1 Holliday junction resolvase homolog Neighboring gene ncRNA Neighboring gene putative imidazolonepropionase Neighboring gene Serpentine receptor class gamma-8 Neighboring gene ncRNA Neighboring gene Serpentine receptor class gamma-9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase is indispensable for oogenesis, oocyte-to-embryo transition, and larval development of the nematode Caenorhabditis elegans. Kanaki N, et al. Glycobiology, 2019 Feb 1. PMID 30445613, Free PMC Article
    2. Identification of a novel ADAMTS9/GON-1 function for protein transport from the ER to the Golgi. Yoshina S, et al. Mol Biol Cell, 2012 May. PMID 22419820, Free PMC Article
    3. RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database. Akiyoshi S, et al. Glycobiology, 2015 Jan. PMID 25091817, Free PMC Article
    4. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
    5. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oligosaccharyl transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in post-translational protein modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt-3
    NP_498362.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6248642..6251607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065961.6 → NP_498362.1  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498362.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46975
      Conserved Domains (2) summary
      COG1287
      Location:22 → 751
      Stt3; Asparagine N-glycosylation enzyme, membrane subunit Stt3 [Posttranslational modification, protein turnover, chaperones]
      pfam02516
      Location:19 → 506
      STT3; Oligosaccharyl transferase STT3 subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46975.1

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