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    atfs-1 Stress activated transcription factor atfs-1 [ Caenorhabditis elegans ]

    Gene ID: 179922, updated on 2-Nov-2024

    Summary

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    Official Symbol
    atfs-1
    Official Full Name
    Stress activated transcription factor atfs-1
    Primary source
    WormBase:WBGene00013878
    Locus tag
    CELE_ZC376.7
    See related
    AllianceGenome:WB:WBGene00013878
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding activity; and mitochondrial transcription factor activity. Involved in several processes, including mitochondrial unfolded protein response; positive regulation of nematode larval development; and regulation of gene expression. Located in mitochondrial matrix and nucleus. Is expressed in intestine. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human ATF4 (activating transcription factor 4). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See atfs-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (14194446..14197697)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene tRNA (guanine(26)-N(2))-dimethyltransferase Neighboring gene INTegrator complex Subunit homolog Neighboring gene BTB domain-containing protein Neighboring gene Seven TM Receptor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response. Lin YF, et al. Nature, 2016 May 19. PMID 27135930, Free PMC Article
    2. The UPRmt preserves mitochondrial import to extend lifespan. Xin N, et al. J Cell Biol, 2022 Jul 4. PMID 35608535, Free PMC Article
    3. UPR(mt) scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans. Shpilka T, et al. Nat Commun, 2021 Jan 20. PMID 33473112, Free PMC Article
    4. Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt). Nargund AM, et al. Mol Cell, 2015 Apr 2. PMID 25773600, Free PMC Article
    5. Microbial Genetic Composition Tunes Host Longevity. Han B, et al. Cell, 2017 Jun 15. PMID 28622510, Free PMC Article

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans.
      Title: V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans.
    2. The UPRmt preserves mitochondrial import to extend lifespan.
      Title: The UPRmt preserves mitochondrial import to extend lifespan.
    3. Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors.
      Title: Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors.
    4. FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation.
      Title: FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation.
    5. LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria.
      Title: LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria.
    6. Caenorhabditis elegans homologue of Fam210 is required for oogenesis and reproduction.
      Title: Caenorhabditis elegans homologue of Fam210 is required for oogenesis and reproduction.
    7. ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.
      Title: ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.
    8. While loss of atfs-1 during adulthood does not affect lifespan in any of these strains, absence of atfs-1 during development prevents clk-1 and isp-1 worms from reaching adulthood and reduces the lifespan of nuo-6 mutants.
      Title: Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways.
    9. Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the mitochondrial unfolded protein response.
      Title: Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt).
    10. The bZip transcription factor ATFS-1 mediates mitochondrial stress-induced autophagy.
      Title: Genome-wide screen identifies signaling pathways that regulate autophagy during Caenorhabditis elegans development.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mitochondrial transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitochondrial transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Stress activated transcription factor atfs-1
    NP_001024302.1
    • Confirmed by transcript evidence
    NP_001256571.1
    • Confirmed by transcript evidence
    NP_506515.1
    • Confirmed by transcript evidence
    NP_872160.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14194446..14197697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_182360.9 → NP_872160.1  Stress activated transcription factor atfs-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872160.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23272
      Conserved Domains (1) summary
      cd14692
      Location:405 → 467
      bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain

    2. NM_074114.7 → NP_506515.1  Stress activated transcription factor atfs-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506515.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E5QCH2, Q23272, Q52GY6, Q8I4B7
      Conserved Domains (1) summary
      cd14692
      Location:421 → 483
      bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain

    3. NM_001029131.6 → NP_001024302.1  Stress activated transcription factor atfs-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024302.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23272
      Conserved Domains (1) summary
      cd14692
      Location:407 → 469
      bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain

    4. NM_001269642.3 → NP_001256571.1  Stress activated transcription factor atfs-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256571.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23272
      Conserved Domains (2) summary
      cd09726
      Location:136 → 277
      RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein
      cd14692
      Location:214 → 276
      bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23272.1

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