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    bgal-1 Beta-galactosidase [ Caenorhabditis elegans ]

    Gene ID: 188583, updated on 2-Nov-2024

    Summary

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    Official Symbol
    bgal-1
    Official Full Name
    Beta-galactosidase
    Primary source
    WormBase:WBGene00011832
    Locus tag
    CELE_T19B10.3
    See related
    AllianceGenome:WB:WBGene00011832
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable beta-galactosidase activity. Predicted to be involved in galactose catabolic process. Predicted to be active in vacuole. Is expressed in head mesodermal cell. Human ortholog(s) of this gene implicated in GM1 gangliosidosis (multiple) and mucopolysaccharidosis IV (multiple). Orthologous to several human genes including GLB1L (galactosidase beta 1 like). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See bgal-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (11222931..11226018, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 Neighboring gene DUF19 domain-containing protein Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes. Venz R, et al. Geroscience, 2024 Apr. PMID 37644339, Free PMC Article
    2. mRNA profiling reveals significant transcriptional differences between a multipotent progenitor and its differentiated sister. Mathies LD, et al. BMC Genomics, 2019 May 28. PMID 31138122, Free PMC Article
    3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables beta-galactosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Beta-galactosidase
    NP_505849.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11222931..11226018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073448.10 → NP_505849.2  Beta-galactosidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505849.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q27526
      Conserved Domains (1) summary
      pfam01301
      Location:50 → 369
      Glyco_hydro_35; Glycosyl hydrolases family 35
    Nucleotide Protein
    Heading Accession and Version

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