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    C8orf74 chromosome 8 open reading frame 74 [ Homo sapiens (human) ]

    Gene ID: 203076, updated on 10-Oct-2024

    Summary

    Official Symbol
    C8orf74provided by HGNC
    Official Full Name
    chromosome 8 open reading frame 74provided by HGNC
    Primary source
    HGNC:HGNC:32296
    See related
    Ensembl:ENSG00000171060 AllianceGenome:HGNC:32296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Restricted expression toward testis (RPKM 4.0) See more
    Orthologs
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    Genomic context

    See C8orf74 in Genome Data Viewer
    Location:
    8p23.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (10672628..10700590)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (9038498..9066367, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (10530138..10558100)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10469845-10470570 Neighboring gene MPRA-validated peak6901 silencer Neighboring gene RP1 like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10489151-10489860 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10493333-10494238 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10494239-10495144 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10503027-10503883 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10535715-10536216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10536217-10536716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10536733-10537272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10537273-10537810 Neighboring gene microRNA 4286 Neighboring gene RNA, 5S ribosomal pseudogene 252 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10567701-10568468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10568469-10569236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18914 Neighboring gene uncharacterized LOC102723313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18915 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10589078-10589902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10591664-10592306 Neighboring gene CRE3 CAGE-defined tissue-specific enhancer Neighboring gene SRY-box transcription factor 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:10616720-10616853 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:10632670-10632869 Neighboring gene PIN2 (TERF1) interacting telomerase inhibitor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10647506-10648006 Neighboring gene microRNA 1322

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    uncharacterized protein C8orf74

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040032.2NP_001035121.2  uncharacterized protein C8orf74

      Status: VALIDATED

      Source sequence(s)
      AC105001
      Consensus CDS
      CCDS47800.1
      UniProtKB/Swiss-Prot
      A2RUD6, Q6P047
      UniProtKB/TrEMBL
      A0AAG2TK55
      Related
      ENSP00000307129.5, ENST00000304519.10
      Conserved Domains (1) summary
      pfam14769
      Location:102129
      CLAMP; Flagellar C1a complex subunit C1a-32

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      10672628..10700590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421493.1XP_047277449.1  uncharacterized protein C8orf74 isoform X1

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654717.1 Reference GRCh38.p14 PATCHES

      Range
      2646603..2674481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332240.1XP_054188215.1  uncharacterized protein C8orf74 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      9038498..9066367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359996.1XP_054215971.1  uncharacterized protein C8orf74 isoform X3