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    ZSCAN23 zinc finger and SCAN domain containing 23 [ Homo sapiens (human) ]

    Gene ID: 222696, updated on 17-Jun-2024

    Summary

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    Official Symbol
    ZSCAN23provided by HGNC
    Official Full Name
    zinc finger and SCAN domain containing 23provided by HGNC
    Primary source
    HGNC:HGNC:21193
    See related
    Ensembl:ENSG00000187987 AllianceGenome:HGNC:21193
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF390; ZNF453; dJ29K1.3; dJ29K1.3.1
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See ZSCAN23 in Genome Data Viewer
    Location:
    6p22.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (28421400..28443491, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (28290130..28314932, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (28400432..28411268, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 968, pseudogene Neighboring gene RNA, U2 small nuclear 45, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:28384184-28384684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:28384685-28385185 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:28390954-28392153 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:28411067-28411577 Neighboring gene COX11 pseudogene 1 Neighboring gene olfactory receptor family 2 subfamily E member 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Preliminary RNA-Seq Analysis of Long Non-Coding RNAs Expressed in Human Term Placenta. Majewska M, et al. Int J Mol Sci, 2018 Jun 27. PMID 29954144, Free PMC Article
    2. A conserved acetylation switch enables pharmacological control of tubby-like protein stability. Kerek EM, et al. J Biol Chem, 2021 Jan-Jun. PMID 33187986, Free PMC Article
    3. A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. Blandin G, et al. Skelet Muscle, 2013 Feb 15. PMID 23414517, Free PMC Article
    4. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
    5. The DNA sequence and analysis of human chromosome 6. Mungall AJ, et al. Nature, 2003 Oct 23. PMID 14574404

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epigenetic silencing ZSCAN23 promotes pancreatic cancer growth by activating Wnt signaling.
      Title: Epigenetic silencing ZSCAN23 promotes pancreatic cancer growth by activating Wnt signaling.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ99276, MGC126606, MGC126608

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and SCAN domain-containing protein 23
    Names
    zinc finger protein 390
    zinc finger protein 453

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012455.2 → NP_001012458.1  zinc finger and SCAN domain-containing protein 23

      See identical proteins and their annotated locations for NP_001012458.1

      Status: VALIDATED

      Source sequence(s)
      AL833347, BX283350, Z98745
      Consensus CDS
      CCDS47393.1
      UniProtKB/Swiss-Prot
      Q3MJ62, Q96KV9
      Related
      ENSP00000289788.4, ENST00000289788.5
      Conserved Domains (6) summary
      smart00431
      Location:44 → 156
      SCAN; leucine rich region
      COG5048
      Location:215 → 384
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:251 → 271
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:249 → 271
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:45 → 132
      SCAN; SCAN domain
      pfam13465
      Location:264 → 288
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      28421400..28443491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418384.1 → XP_047274340.1  zinc finger and SCAN domain-containing protein 23 isoform X1

      UniProtKB/Swiss-Prot
      Q3MJ62, Q96KV9

    RNA

    1. XR_007059226.1 RNA Sequence

    2. XR_007059223.1 RNA Sequence

    3. XR_007059224.1 RNA Sequence

    4. XR_007059225.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      28290130..28314932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354667.1 → XP_054210642.1  zinc finger and SCAN domain-containing protein 23 isoform X1

      UniProtKB/Swiss-Prot
      Q3MJ62, Q96KV9

    RNA

    1. XR_008487284.1 RNA Sequence

    2. XR_008487281.1 RNA Sequence

    3. XR_008487282.1 RNA Sequence

    4. XR_008487283.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3MJ62.1 GenPept UniProtKB/Swiss-Prot:Q3MJ62

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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