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    Hrh4 histamine receptor H4 [ Mus musculus (house mouse) ]

    Gene ID: 225192, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hrh4provided by MGI
    Official Full Name
    histamine receptor H4provided by MGI
    Primary source
    MGI:MGI:2429635
    See related
    Ensembl:ENSMUSG00000037346 AllianceGenome:MGI:2429635
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H4; H4R; BG26; HH4R; AXOR35; GPRv53; GPCR105
    Summary
    Enables histamine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; and chemical synaptic transmission. Predicted to act upstream of or within inflammatory response. Located in membrane. Orthologous to human HRH4 (histamine receptor H4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 1.0) and spleen adult (RPKM 0.1) See more
    Orthologs
    human all
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    Genomic context

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    See Hrh4 in Genome Data Viewer
    Location:
    18 A1; 18 6.88 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (13140039..13156758)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (13006982..13023701)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 1A Neighboring gene ribosomal protein S8 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9448 Neighboring gene impact, RWD domain protein Neighboring gene ribosomal protein SA pseudogene Neighboring gene predicted gene, 36563

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increased expression of the histamine H4 receptor subtype in hypertrophic differentiation of chondrogenic ATDC5 cells. Yamaura K, et al. J Cell Biochem, 2012 Mar. PMID 22065367
    2. Histamine H4 receptor knockout mice display reduced inflammation in a chronic model of atopic dermatitis. Rossbach K, et al. Allergy, 2016 Feb. PMID 26440543
    3. Proinflammatory role of the histamine H4 receptor in dextrane sodium sulfate-induced acute colitis. Schirmer B, et al. Biochem Pharmacol, 2015 Nov 1. PMID 26365468
    4. The histamine H4 -receptor (H4 R) regulates eosinophilic inflammation in ovalbumin-induced experimental allergic asthma in mice. Hartwig C, et al. Eur J Immunol, 2015 Apr. PMID 25501767
    5. Involvement of histamine 4 receptor in the pathogenesis and progression of rheumatoid arthritis. Abd-Allah AR, et al. Int Immunol, 2014 Jun. PMID 24402309

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Interplay between Histamine H4 Receptor and the Kidney Function: The Lesson from H4 Receptor Knockout Mice.
      Title: The Interplay between Histamine H(4) Receptor and the Kidney Function: The Lesson from H(4) Receptor Knockout Mice.
    2. The Histamine H4 Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A3 Receptor Agonist IB-MECA: Role of CD4(+) T Cells.
      Title: The Histamine H(4) Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A(3) Receptor Agonist IB-MECA: Role of CD4(+) T Cells.
    3. The Novel H4R Antagonist 1-[(5-Chloro-2,3-Dihydro-1-Benzofuran-2-Yl)Methyl]-4-Methyl-Piperazine (LINS01007) Attenuates Several Symptoms in Murine Allergic Asthma.
      Title: The Novel H(4)R Antagonist 1-[(5-Chloro-2,3-Dihydro-1-Benzofuran-2-Yl)Methyl]-4-Methyl-Piperazine (LINS01007) Attenuates Several Symptoms in Murine Allergic Asthma.
    4. Study of the antitumour effects and the modulation of immune response by histamine in breast cancer.
      Title: Study of the antitumour effects and the modulation of immune response by histamine in breast cancer.
    5. Findings show an effective role of HrH4 in adipose tissue browning.
      Title: Stimulation of histamine H4 receptor participates in cold-induced browning of subcutaneous white adipose tissue.
    6. Study using adoptive transfer of eosinophils from H4R-deficient and H4R-competentmice to dextran sodium sulfate-induced colitis in IL-5-deficient mice demonstrate that as well as in vitro, also in vivo histamine via the H4R only partially activates eosinophils.
      Title: In vivo Evidence for Partial Activation of Eosinophils via the Histamine H(4)-Receptor: Adoptive Transfer Experiments Using Eosinophils From H(4)R(-/-) and H(4)R(+/+) Mice.
    7. Rac1 and Rac2 have distinct and essential roles in intracellular signaling downstream of H4 receptor-PI3K in histamine-induced chemotaxis of mast cells
      Title: Distinct Roles of Small GTPases Rac1 and Rac2 in Histamine H(4) Receptor-Mediated Chemotaxis of Mast Cells.
    8. Study results indicate that persistent ERK activation via the histamine H4 receptor in spinal neurons underlies dinitrofluorobenzene-induced chronic itch.
      Title: Persistent Extracellular Signal-Regulated Kinase Activation by the Histamine H4 Receptor in Spinal Neurons Underlies Chronic Itch.
    9. Results suggest that TNF-alpha mRNA expression via histamine H4 receptors may contribute to the development of cisplatin-induced anorexia, and that histamine H4 receptor antagonists are potentially useful treatments.
      Title: Effects of a histamine H(4) receptor antagonist on cisplatin-induced anorexia in mice.
    10. colonic mast cells-derived histamine initiates granulocyte infiltration into the colonic mucosa through H4R
      Title: Histamine drives severity of innate inflammation via histamine 4 receptor in murine experimental colitis.
    Submit: New GeneRIF Correction See all GeneRIFs (48)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130500

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histamine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histamine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histamine receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within inflammatory response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    histamine H4 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153087.2 → NP_694727.1  histamine H4 receptor

      See identical proteins and their annotated locations for NP_694727.1

      Status: VALIDATED

      Source sequence(s)
      AC131672
      Consensus CDS
      CCDS29069.1
      UniProtKB/Swiss-Prot
      Q91ZY2
      Related
      ENSMUSP00000041061.3, ENSMUST00000041676.3
      Conserved Domains (1) summary
      pfam00001
      Location:32 → 360
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      13140039..13156758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317874.1 → XP_017173363.1  histamine H4 receptor isoform X2

      UniProtKB/TrEMBL
      B2ZGH2
      Related
      ENSMUSP00000157130.2, ENSMUST00000234565.2
      Conserved Domains (2) summary
      cd14964
      Location:18 → 42
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:16 → 129
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_006525817.2 → XP_006525880.1  histamine H4 receptor isoform X1

      See identical proteins and their annotated locations for XP_006525880.1

      UniProtKB/TrEMBL
      Q2M2N7
      Conserved Domains (2) summary
      cd14964
      Location:5 → 21
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:1 → 247
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZY2.1 GenPept UniProtKB/Swiss-Prot:Q91ZY2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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