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    Klhl34 kelch-like 34 [ Mus musculus (house mouse) ]

    Gene ID: 245683, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Klhl34provided by MGI
    Official Full Name
    kelch-like 34provided by MGI
    Primary source
    MGI:MGI:2685234
    See related
    Ensembl:ENSMUSG00000047485 AllianceGenome:MGI:2685234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm388
    Summary
    Is expressed in central nervous system. Orthologous to human KLHL34 (kelch like family member 34). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human all
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    Genomic context

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    See Klhl34 in Genome Data Viewer
    Location:
    X F4; X 72.76 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (156600919..156603658)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (157818435..157821060)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene small muscle protein, X-linked Neighboring gene predicted gene 15169 Neighboring gene STARR-seq mESC enhancer starr_48160 Neighboring gene connector enhancer of kinase suppressor of Ras 2 Neighboring gene STARR-seq mESC enhancer starr_48161 Neighboring gene STARR-seq mESC enhancer starr_48162 Neighboring gene aldolase A, fructose-bisphosphate pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 34

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081667.3 → NP_001075136.1  kelch-like protein 34

      Status: VALIDATED

      Source sequence(s)
      AL732396
      Consensus CDS
      CCDS41191.1
      UniProtKB/TrEMBL
      A2AI76
      Related
      ENSMUSP00000084399.5, ENSMUST00000087157.5
      Conserved Domains (6) summary
      smart00225
      Location:30 → 126
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:131 → 235
      BACK; BTB And C-terminal Kelch
      sd00038
      Location:358 → 411
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:19 → 122
      BTB; BTB/POZ domain
      pfam01344
      Location:515 → 558
      Kelch_1; Kelch motif
      pfam13415
      Location:424 → 470
      Kelch_3; Galactose oxidase, central domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      156600919..156603658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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