Prph peripherin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prphprovided by RGD
Official Full Name: peripherinprovided by RGD
Primary source: RGD:3414
See related: EnsemblRapid:ENSRNOG00000052880 AllianceGenome:RGD:3414
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Perf; Prph1
Summary: Predicted to enable structural molecule activity. Involved in intermediate filament cytoskeleton organization. Located in neuronal cell body; terminal bouton; and type III intermediate filament. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 1. Orthologous to human PRPH (peripherin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 34.2), Brain (RPKM 24.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (132096888..132101070)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (130218149..130222136)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (140742406..140746197)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonistrated that differential expression of peripherin and NF-H after injury occurs in both cutaneous and muscular afferent neurons after injury.
Title: Peripherin and ATF3 genes are differentially regulated in regenerating and non-regenerating primary sensory neurons.
Using a morphological approach that peripherin expression in subpopulations within the dorsal root ganglia sensory neurons. And peripherin is specifically expressed in unmyelinated fibers.
Title: Neuronal intermediate filament expression in rat dorsal root ganglia sensory neurons: an in vivo and in vitro study.
By birth, and for 2 or 3 days, peripherin expression was gradually restricted to the type II neuronal population and their projections.
Title: New insights into peripherin expression in cochlear neurons.
peripherin is a novel substrate for Akt in vivo and its phosphorylation may play a role in motor nerve regeneration
Title: Identification of peripherin as a Akt substrate in neurons.
Peripherin nitration is not restricted to PC12 cells but it is also present in vivo in rat brain.
Title: Tyrosine nitration is a novel post-translational modification occurring on the neural intermediate filament protein peripherin.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC104164P1 (e-PCR)
- UniSTS:270103

D7Mit9 (e-PCR), detects polymorphism
- UniSTS:119608

D7Wox24 (e-PCR)
- UniSTS:118115

RH94483 (e-PCR)
- UniSTS:119731

RH133745 (e-PCR)
- UniSTS:217028

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intermediate filament cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intermediate filament cytoskeleton organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in C-fiber	ISO Inferred from Sequence Orthology more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
located_in neurofilament	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	ISO Inferred from Sequence Orthology more info
is_active_in type III intermediate filament	IBA Inferred from Biological aspect of Ancestor more info
located_in type III intermediate filament	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peripherin

Names: peripherin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012633.3 → NP_036765.3 peripherin

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P21807

UniProtKB/TrEMBL

A6KCD5

Related

ENSRNOP00000072008.2, ENSRNOT00000089211.3

Conserved Domains (2) summary

pfam00038
Location:99 → 409

Filament; Intermediate filament protein

pfam04732
Location:21 → 98

Filament_head; Intermediate filament head (DNA binding) region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

132096888..132101070

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008765669.4 → XP_008763891.1 peripherin isoform X2

UniProtKB/TrEMBL

A0A8I6AT59, Q496Z5

Conserved Domains (2) summary

pfam00038
Location:99 → 441

Filament; Intermediate filament protein

pfam04732
Location:21 → 98

Filament_head; Intermediate filament head (DNA binding) region
XM_006257321.5 → XP_006257383.1 peripherin isoform X1

See identical proteins and their annotated locations for XP_006257383.1

UniProtKB/Swiss-Prot

P21807

UniProtKB/TrEMBL

A6KCD4

Related

ENSRNOP00000097710.2, ENSRNOT00000094354.2

Conserved Domains (2) summary

pfam00038
Location:99 → 441

Filament; Intermediate filament protein

pfam04732
Location:21 → 98

Filament_head; Intermediate filament head (DNA binding) region
XM_063262998.1 → XP_063119068.1 peripherin isoform X3

UniProtKB/TrEMBL

F1M7P4, Q496Z5