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    SPCC18B5.06 putative translation release factor eRF1 family protein [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539371, updated on 17-May-2024

    Summary

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    Gene symbol
    SPCC18B5.06
    Gene description
    putative translation release factor eRF1 family protein
    Primary source
    PomBase:SPCC18B5.06
    Locus tag
    SPCC18B5.06
    See related
    FungiDB:SPCC18B5.06; VEuPathDB:SPCC18B5.06
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See SPCC18B5.06 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003421.2 (729054..730829)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene putative phosphomethylpyrimidine kinase Neighboring gene putative mitochondrial ribosomal protein subunit S18 Neighboring gene nucleoporin Nup61 Neighboring gene putative isoleucine--tRNA (Ile) ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The stretch of C-terminal acidic amino acids of translational release factor eRF1 is a primary binding site for eRF3 of fission yeast. Ito K, et al. RNA, 1998 Aug. PMID 9701287, Free PMC Article
    2. Structure of the Dom34-Hbs1 complex and implications for no-go decay. Chen L, et al. Nat Struct Mol Biol, 2010 Oct. PMID 20890290
    3. Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe. Guydosh NR, et al. Elife, 2017 Sep 25. PMID 28945192, Free PMC Article
    4. C-terminal interaction of translational release factors eRF1 and eRF3 of fission yeast: G-domain uncoupled binding and the role of conserved amino acids. Ebihara K, et al. RNA, 1999 Jun. PMID 10376874, Free PMC Article
    5. Structural insights into eRF3 and stop codon recognition by eRF1. Cheng Z, et al. Genes Dev, 2009 May 1. PMID 19417105, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables GTPase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation release factor activity IC
    Inferred by Curator
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA surveillance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic translational termination EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nonfunctional rRNA decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, no-go decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, non-stop decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Dom34-Hbs1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    putative translation release factor eRF1 family protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      729054..730829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022927.2 → NP_587936.1  putative translation release factor eRF1 family protein [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587936.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9USL5
      Conserved Domains (1) summary
      COG1537
      Location:1 → 370
      PelA; Stalled ribosome rescue protein Dom34, pelota family [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    3MCA_B.1

    Gene LinkOut

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    Research Materials