U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    apn2 AP-endonuclease Apn2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540679, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    apn2
    Official Full Name
    AP-endonuclease Apn2
    Primary source
    PomBase:SPBC3D6.10
    Locus tag
    SPOM_SPBC3D6.10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See apn2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (1287389..1290094)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA polymerase epsilon subunit Dpb4 Neighboring gene SUMO-targeted ubiquitin-protein ligase E3 Slx8 Neighboring gene ncRNA Neighboring gene U3 snoRNA associated protein Dip2 Neighboring gene disulfide isomerase Pdi3

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Fission yeast Uve1 and Apn2 function in distinct oxidative damage repair pathways in vivo. Fraser JL, et al. DNA Repair (Amst), 2003 Nov 21. PMID 14599746
    2. Interaction of apurinic/apyrimidinic endonuclease 2 (Apn2) with Myh1 DNA glycosylase in fission yeast. Jin J, et al. DNA Repair (Amst), 2014 Mar. PMID 24559510, Free PMC Article
    3. Roles of base excision repair enzymes Nth1p and Apn2p from Schizosaccharomyces pombe in processing alkylation and oxidative DNA damage. Sugimoto T, et al. DNA Repair (Amst), 2005 Nov 21. PMID 16076563
    4. The major role of human AP-endonuclease homolog Apn2 in repair of abasic sites in Schizosaccharomyces pombe. Ribar B, et al. Nucleic Acids Res, 2004. PMID 14704348, Free PMC Article
    5. AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe. Nilsen L, et al. Nucleic Acids Res, 2012 Mar. PMID 22084197, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thus, Myh1 and Apn2 constitute an initial base excision complex in Schizosaccharomyces pombe.
      Title: Interaction of apurinic/apyrimidinic endonuclease 2 (Apn2) with Myh1 DNA glycosylase in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA 3'-5' DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA 3'-5' DNA exonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphodiesterase I activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoric diester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in base-excision repair EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    AP-endonuclease Apn2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1287389..1290094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021431.3 → NP_595522.1  AP-endonuclease Apn2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595522.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P87175
      Conserved Domains (2) summary
      cd09088
      Location:2 → 302
      Ape2-like_AP-endo; Human Ape2-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases
      pfam06839
      Location:456 → 513
      zf-GRF; GRF zinc finger
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials