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    tif225 putative translation initiation factor eIF2B epsilon subunit tif225 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542017, updated on 20-May-2024

    Summary

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    Gene symbol
    tif225
    Gene description
    putative translation initiation factor eIF2B epsilon subunit tif225
    Primary source
    PomBase:SPAC8C9.15c
    Locus tag
    SPAC8C9.15c
    See related
    FungiDB:SPAC8C9.15c; VEuPathDB:SPAC8C9.15c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See tif225 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003424.3 (3669130..3671512, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene putative mitochondrial iron ion transporter Neighboring gene transcription factor Prr1 Neighboring gene TLDc domain protein 1 Neighboring gene DASH complex subunit Spc34 Neighboring gene ABC family Fe transporter Atm1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of eIF2B and insights into eIF2-eIF2B interactions. Kashiwagi K, et al. FEBS J, 2017 Mar. PMID 27627185
    2. Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B. Kashiwagi K, et al. J Struct Funct Genomics, 2016 Mar. PMID 27023709, Free PMC Article
    3. Structural basis for eIF2B inhibition in integrated stress response. Kashiwagi K, et al. Science, 2019 May 3. PMID 31048492
    4. Crystal structure of eukaryotic translation initiation factor 2B. Kashiwagi K, et al. Nature, 2016 Mar 3. PMID 26901872
    5. Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries. Wang J, et al. Genes Dev, 2013 Sep 1. PMID 24013502, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    part_of eukaryotic translation initiation factor 2B complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 2B complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative translation initiation factor eIF2B epsilon subunit tif225

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3669130..3671512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019708.2 → NP_594285.1  putative translation initiation factor eIF2B epsilon subunit tif225 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594285.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P56287
      Conserved Domains (3) summary
      cd05787
      Location:332 → 410
      LbH_eIF2B_epsilon; eIF-2B epsilon subunit, central Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is ...
      cd04197
      Location:18 → 231
      eIF-2B_epsilon_N; The N-terminal domain of epsilon subunit of the eIF-2B is a subfamily of glycosyltransferase 2
      cd11558
      Location:510 → 667
      W2_eIF2B_epsilon; C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon
    Nucleotide Protein
    Heading Accession and Version

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