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    rlc1 myosin II regulatory light chain Rlc1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543545, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rlc1
    Official Full Name
    myosin II regulatory light chain Rlc1
    Primary source
    PomBase:SPAC926.03
    Locus tag
    SPOM_SPAC926.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rlc1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (3887262..3888497)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene NADH-dependent flavin oxidoreductase Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene protein tyrosine phosphatase Stp1 Neighboring gene ncRNA Neighboring gene protein Ina22 Neighboring gene Hsp90 chaperone Neighboring gene 5S ribosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of fission yeast myosin-II function and contractile ring dynamics by regulatory light-chain and heavy-chain phosphorylation. Sladewski TE, et al. Mol Biol Cell, 2009 Sep. PMID 19570908, Free PMC Article
    2. Type II myosin regulatory light chain relieves auto-inhibition of myosin-heavy-chain function. Naqvi NI, et al. Nat Cell Biol, 2000 Nov. PMID 11056543
    3. Schizosaccharomyces pombe Pak-related protein, Pak1p/Orb2p, phosphorylates myosin regulatory light chain to inhibit cytokinesis. Loo TH, et al. J Cell Biol, 2008 Dec 1. PMID 19029336, Free PMC Article
    4. The S. pombe rlc1 gene encodes a putative myosin regulatory light chain that binds the type II myosins myo3p and myo2p. Le Goff X, et al. J Cell Sci, 2000 Dec. PMID 11069761
    5. Fission yeast myosin Myo2 is down-regulated in actin affinity by light chain phosphorylation. Pollard LW, et al. Proc Natl Acad Sci U S A, 2017 Aug 29. PMID 28808035, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results describe the role of regulatory light-chain (Rlc1p) and heavy-chain phosphorylation in controlling fission yeast myosin-II (Myo2p) motor activity and function during cytokinesis.
      Title: Regulation of fission yeast myosin-II function and contractile ring dynamics by regulatory light-chain and heavy-chain phosphorylation.
    2. Schizosaccharomyces pombe Pak-related protein, Pak1p/Orb2p, phosphorylates myosin II regulatory light chain (Rlc1p) to inhibit cytokinesis.
      Title: Schizosaccharomyces pombe Pak-related protein, Pak1p/Orb2p, phosphorylates myosin regulatory light chain to inhibit cytokinesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables calcium ion binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables cytoskeletal motor regulator activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables cytoskeletal motor regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables myosin heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic actomyosin contractile ring contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in medial cortical node IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring, distal actin filament layer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin II complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    myosin II regulatory light chain Rlc1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3887262..3888497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019785.3 → NP_594364.1  myosin II regulatory light chain Rlc1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594364.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UUG5
      Conserved Domains (3) summary
      COG5126
      Location:35 → 183
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:49 → 106
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl08302
      Location:118 → 178
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version

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