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    mt-Nd4 NADH dehydrogenase 4, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 26201, updated on 29-Feb-2024

    Summary

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    Official Symbol
    mt-Nd4provided by RGD
    Official Full Name
    NADH dehydrogenase 4, mitochondrialprovided by RGD
    Primary source
    RGD:620559
    See related
    AllianceGenome:RGD:620559
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus (strain: BN/SsNHsdMCW)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ND4
    Summary
    Predicted to enable NADH dehydrogenase (ubiquinone) activity and ubiquinone binding activity. Predicted to contribute to NADH dehydrogenase activity. Involved in several processes, including response to ethanol; response to hypoxia; and response to nicotine. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; Parkinson's disease; macular degeneration; and schizophrenia. Orthologous to human MT-ND4 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See mt-Nd4 in Genome Data Viewer
    Annotation release Status Assembly Chr Location
    RS_2023_06 latest, but not current mRatBN7.2 (GCF_015227675.2) MT (non-nuclear) NC_001665.2 (10160..11537)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) MT (non-nuclear) NC_001665.2 (10160..11537)

    Chromosome MT - NC_001665.2Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase subunit 3 Neighboring gene tRNA-Arg Neighboring gene NADH dehydrogenase subunit 4L Neighboring gene tRNA-His Neighboring gene tRNA-Ser Neighboring gene tRNA-Leu

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of mitochondrial replication and transcription control during rat early development in vivo and in vitro. Kameyama Y, et al. Reproduction, 2007 Feb. PMID 17307910
    2. Differential expression of mitochondrial NADH dehydrogenase in ethanol-treated rat brain: revealed by differential display. Chen W, et al. Alcohol Clin Exp Res, 1997 Sep. PMID 9309317
    3. Significant modulation of mitochondrial electron transport system by nicotine in various rat brain regions. Wang J, et al. Mitochondrion, 2009 Jun. PMID 19460297, Free PMC Article
    4. Oxygen tension regulates mitochondrial DNA-encoded complex I gene expression. Piruat JI, et al. J Biol Chem, 2005 Dec 30. PMID 16257962
    5. Content of mitochondrial DNA and of three mitochondrial RNAs in developing and adult rat cerebellum. Renis M, et al. J Neurochem, 1989 Mar. PMID 2465379

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inherited variation mt-Nd2, mt-Nd4, and mt-Nd5 can influence glucose and lipid metabolism when expressed on the nuclear genetic background of the SHR strain.
      Title: Nonsynonymous variants in mt-Nd2, mt-Nd4, and mt-Nd5 are linked to effects on oxidative phosphorylation and insulin sensitivity in rat conplastic strains.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • NADH4

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NADH dehydrogenase (ubiquinone) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to NADH dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquinone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cerebellum development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in electron transport coupled proton transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in in utero embryonic development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, NADH to ubiquinone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nicotine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Names
    NADH dehydrogenase subunit 4
    YP_665638.1
    • TAA stop codon is completed by the addition of 3' A residues to the mRNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001665.2 Reference assembly

      Range
      10160..11537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_665638.1 NADH dehydrogenase subunit 4 (mitochondrion) [Rattus norvegicus]

      See identical proteins and their annotated locations for YP_665638.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P05508, Q9T528
      UniProtKB/TrEMBL
      Q06Q89, Q8HIC6
      Related
      ENSRNOP00000043141.3
      Conserved Domains (1) summary
      MTH00110
      Location:1 → 459
      ND4; NADH dehydrogenase subunit 4; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05508.3

    Gene LinkOut

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