mt-Nd5 NADH dehydrogenase 5, mitochondrial [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: mt-Nd5provided by RGD
Official Full Name: NADH dehydrogenase 5, mitochondrialprovided by RGD
Primary source: RGD:620560
See related: AllianceGenome:RGD:620560
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus (strain: BN/SsNHsdMCW)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ND5
Summary: Predicted to enable NADH dehydrogenase (ubiquinone) activity. Involved in response to hydrogen peroxide; response to hypoxia; and response to organonitrogen compound. Located in neuron projection. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; Leigh disease; and MELAS syndrome. Orthologous to human MT-ND5 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
RS_2023_06	latest, but not current	mRatBN7.2 (GCF_015227675.2)	MT (non-nuclear)	NC_001665.2 (11736..13565)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	MT (non-nuclear)	NC_001665.2 (11736..13565)

Chromosome MT - NC_001665.2 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Inherited variation mt-Nd2, mt-Nd4, and mt-Nd5 can influence glucose and lipid metabolism when expressed on the nuclear genetic background of the SHR strain.
Title: Nonsynonymous variants in mt-Nd2, mt-Nd4, and mt-Nd5 are linked to effects on oxidative phosphorylation and insulin sensitivity in rat conplastic strains.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to NADH dehydrogenase (ubiquinone) activity	ISO Inferred from Sequence Orthology more info
enables NADH dehydrogenase (ubiquinone) activity	ISO Inferred from Sequence Orthology more info
enables NADH dehydrogenase (ubiquinone) activity	ISS Inferred from Sequence or Structural Similarity more info
enables NADH dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in electron transport coupled proton transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, NADH to ubiquinone	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial electron transport, NADH to ubiquinone	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of mitochondrial respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial respiratory chain complex I	ISO Inferred from Sequence Orthology more info

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