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    GPR27 G protein-coupled receptor 27 [ Homo sapiens (human) ]

    Gene ID: 2850, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GPR27provided by HGNC
    Official Full Name
    G protein-coupled receptor 27provided by HGNC
    Primary source
    HGNC:HGNC:4482
    See related
    Ensembl:ENSG00000170837 MIM:605187; AllianceGenome:HGNC:4482
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SREB1
    Summary
    GPR27 is a member of the G protein-coupled receptors (GPCRs), a large family of receptors that have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli such as neurotransmitters, hormones, or light induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins.[supplied by OMIM, May 2010]
    Orthologs
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    Genomic context

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    See GPR27 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (71753855..71756496)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (71793122..71795766)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (71803006..71805647)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene FOXP1 divergent transcript Neighboring gene uncharacterized LOC105377155 Neighboring gene NANOG hESC enhancer GRCh37_chr3:71694238-71694747 Neighboring gene eukaryotic translation initiation factor 4E family member 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:71752927-71753508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20064 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14522 Neighboring gene Sharpr-MPRA regulatory region 3624 Neighboring gene uncharacterized LOC105377156 Neighboring gene prokineticin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GPR27 expression correlates with prognosis and tumor progression in gliomas. Cai C, et al. PeerJ, 2024. PMID 38638156, Free PMC Article
    2. Prognostic significance and immune characteristics of GPR27 in gastric cancer. Pan J, et al. Aging (Albany NY), 2023 Sep 12. PMID 37702614, Free PMC Article
    3. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. Matsumoto M, et al. Biochem Biophys Res Commun, 2000 Jun 7. PMID 10833454
    4. Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress. Kotov IN, et al. Mol Oncol, 2014 Dec. PMID 25113059, Free PMC Article
    5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR27 expression correlates with prognosis and tumor progression in gliomas.
      Title: GPR27 expression correlates with prognosis and tumor progression in gliomas.
    2. Prognostic significance and immune characteristics of GPR27 in gastric cancer.
      Title: Prognostic significance and immune characteristics of GPR27 in gastric cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 27
    Names
    super conserved receptor expressed in brain 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018971.3 → NP_061844.1  probable G-protein coupled receptor 27

      See identical proteins and their annotated locations for NP_061844.1

      Status: VALIDATED

      Source sequence(s)
      AC096970
      Consensus CDS
      CCDS2915.1
      UniProtKB/Swiss-Prot
      Q9NS67
      UniProtKB/TrEMBL
      F1DAM3
      Related
      ENSP00000303149.2, ENST00000304411.3
      Conserved Domains (1) summary
      cd15216
      Location:19 → 349
      7tmA_SREB1_GPR27; super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      71753855..71756496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      71793122..71795766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NS67.1 GenPept UniProtKB/Swiss-Prot:Q9NS67

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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