Gpr182 G protein-coupled receptor 182 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr182provided by RGD
Official Full Name: G protein-coupled receptor 182provided by RGD
Primary source: RGD:61903
See related: EnsemblRapid:ENSRNOG00000004311 AllianceGenome:RGD:61903
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Admr
Summary: Enables adrenomedullin receptor activity. Involved in response to hypoxia. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Biomarker of pulmonary hypertension. Orthologous to human GPR182 (G protein-coupled receptor 182). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 117.5), Spleen (RPKM 48.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (65471254..65474110, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (63585997..63589088, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (71044786..71048713, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that stimulation of adrenomedullin/adrenomedullin receptor signaling enhances trophoblast stem cell differentiation; this stimulation involves CALCRL (calcitonin receptor-like receptor) and RAMP2 (receptor activity-modifying protein 2).
Title: Adrenomedullin promotes rat trophoblast stem cell differentiation.
study demonstrates that glomerular gene expression of ADM and its receptors are downregulated during anti-Thy1 glomerulonephritis
Title: Effects of adrenomedullin on the glomerular adrenomedullin system in a rat model of anti-thy1 glomerulonephritis.
The presence of ADM and the gene expression of ADM and its receptor components in the female reproductive system suggest a paracrine effect of ADM on ovarian steroidogenesis.
Title: Coexpression of adrenomedullin and its receptors in the reproductive system of the rat: effects on steroid secretion in rat ovary.
Data indicate that the adrenomedullin receptor subtypes AM1-R and AM2-R are up-regulated in enucleated adrenals, and that this effect depends on the increased local production of AM.
Title: Up-regulation of adrenomedullin receptor gene expression in activated local stem cells during rat adrenal regeneration.
Adrenomedullin inhibits CaCl(2)-induced contraction, without affecting calcium influx, through a CGRP(8-37)-sensitive receptor, but not using the cyclic adenosine monophosphate pathway, probably through activation of protein phosphatases.
Title: Cyclic AMP-independent CGRP8-37-sensitive receptors mediate adrenomedullin-induced decrease of CaCl2-contraction in pregnant rat mesenteric artery.
present study revealed an intimate association between the adrenomedullin signaling system and angiotensin II
Title: Differential gene expression of adrenomedullin receptors in pressure- and volume-overloaded heart--role of angiotensin II.
Nitric oxide increases adrenomedullin receptor function in rat mesangial cells
Title: Nitric oxide increases adrenomedullin receptor function in rat mesangial cells.
expressed in the zona glomerulosa of immature and adult rat adrenals
Title: Adrenomedullin and its receptors are expressed in the zona glomerulosa of immature and adult rat adrenals: evidences of upregulation of ADM system in immature glands.
adrenomedullin, preproadrenomedullin mRNA, adrenomedullin receptors, and specific-binding sites are present in the rat epididymis
Title: Co-expression of adrenomedullin and adrenomedullin receptors in rat epididymis: distinct physiological actions on anion transport.
The increase in functional adrenomedullin receptor during phenotypic change may in part contribute to the development of vascular lesions
Title: Phenotypic changes of adrenomedullin receptor components, RAMP2, and CRLR mRNA expression in cultured rat vascular smooth muscle cells.

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General gene information

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Markers

BE097830 (e-PCR)
- UniSTS:244761

RH129954 (e-PCR)
- UniSTS:213242

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables adrenomedullin receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G-protein coupled receptor 182

Names: G10D; NOW; adrenomedullin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.