Spcs2 signal peptidase complex subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spcs2provided by RGD
Official Full Name: signal peptidase complex subunit 2provided by RGD
Primary source: RGD:1311253
See related: EnsemblRapid:ENSRNOG00000018164 AllianceGenome:RGD:1311253
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311253
Summary: Predicted to be involved in protein targeting to ER and signal peptide processing. Predicted to be integral component of membrane. Predicted to be part of signal peptidase complex. Orthologous to human SPCS2 (signal peptidase complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 191.3), Spleen (RPKM 175.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (163575842..163595269, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (154163724..154183152, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (164829896..164849749, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA943550 (e-PCR)
- UniSTS:250133

RH144009 (e-PCR)
- UniSTS:233255

RH142481 (e-PCR)
- UniSTS:231728

RH144652 (e-PCR)
- UniSTS:233897

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein targeting to ER	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal peptide processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal peptide processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
part_of signal peptidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of signal peptidase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: signal peptidase complex subunit 2

NP_001178530.1

EC 3.4.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191601.1 → NP_001178530.1 signal peptidase complex subunit 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

D3ZD11

Related

ENSRNOP00000024772.4, ENSRNOT00000024772.8

Conserved Domains (1) summary

pfam06703
Location:61 → 216

SPC25; Microsomal signal peptidase 25 kDa subunit (SPC25)