Mical1 microtubule associated monooxygenase, calponin and LIM domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mical1provided by RGD
Official Full Name: microtubule associated monooxygenase, calponin and LIM domain containing 1provided by RGD
Primary source: RGD:1309386
See related: EnsemblRapid:ENSRNOG00000000307 AllianceGenome:RGD:1309386
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nical; MICAL-1
Summary: Predicted to enable several functions, including FAD binding activity; SH3 domain binding activity; and enzyme binding activity. Predicted to be involved in several processes, including actin filament depolymerization; negative regulation of cellular protein metabolic process; and sulfur oxidation. Predicted to be located in several cellular components, including hippocampal mossy fiber expansion; intercellular bridge; and midbody. Orthologous to human MICAL1 (microtubule associated monooxygenase, calponin and LIM domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 172.3), Spleen (RPKM 82.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q12

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (46547983..46568487)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (44974137..44986089)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (46199981..46211930)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In an epilepsy model, optical density values of MICAL-1 expression decreases at all time points after kindling, compared to the normal group.
Title: Expression pattern of Mical-1 in the temporal neocortex of patients with intractable temporal epilepsy and pilocarpine-induced rat model.
Tesults implicate MICALs in neuronal regeneration and support the possibility to attenuate axon repulsion in the injured spinal cord.
Title: MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat.
Using the microtubule depolymerizing drug nocodazole we detected a link between MICAL-1 and -3, and the microtubule cytoskeleton.
Title: The MICAL proteins and rab1: a possible link to the cytoskeleton?

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General gene information

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Markers

RH130593 (e-PCR)
- UniSTS:213877

BE108385 (e-PCR)
- UniSTS:247741

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables F-actin monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables FAD binding	ISO Inferred from Sequence Orthology more info
enables FAD binding	ISS Inferred from Sequence or Structural Similarity more info
enables NAD(P)H oxidase H2O2-forming activity	ISO Inferred from Sequence Orthology more info
enables NADPH oxidase H202-forming activity	IEA Inferred from Electronic Annotation more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament depolymerization	ISO Inferred from Sequence Orthology more info
involved_in actin filament depolymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of regulated secretory pathway	ISO Inferred from Sequence Orthology more info
involved_in sulfur oxidation	ISO Inferred from Sequence Orthology more info
involved_in sulfur oxidation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in actin filament	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in hippocampal mossy fiber expansion	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: [F-actin]-monooxygenase MICAL1; F-actin-monooxygenase MICAL1

Names: NEDD9 interacting protein with calponin homology and LIM domains; [F-actin]-methionine sulfoxide oxidase MICAL1; microtubule associated monoxygenase, calponin and LIM domain containing 1; molecule interacting with CasL protein 1; protein-methionine sulfoxide oxidase MICAL1

NP_001099867.1

EC 1.14.13.225

EC 1.6.3.1

XP_038954550.1

EC 1.14.13.225

EC 1.6.3.1

XP_063135149.1

EC 1.14.13.225

EC 1.6.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106397.1 → NP_001099867.1 [F-actin]-monooxygenase MICAL1

See identical proteins and their annotated locations for NP_001099867.1

Status: PROVISIONAL

Source sequence(s)

CH474025

UniProtKB/Swiss-Prot

D3ZBP4, D3ZJD1

Related

ENSRNOP00000110032.1, ENSRNOT00000129191.1

Conserved Domains (4) summary

cd09358
Location:681 → 734

LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family

pfam01494
Location:85 → 122

FAD_binding_3; FAD binding domain

pfam12130
Location:918 → 1045

DUF3585; Protein of unknown function (DUF3585)

cd21196
Location:506 → 611

CH_MICAL1; calponin homology (CH) domain found in molecule interacting with CasL protein 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

46547983..46568487

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098622.2 → XP_038954550.1 F-actin-monooxygenase MICAL1 isoform X1

Related

ENSRNOP00000000337.5, ENSRNOT00000000337.6

Conserved Domains (4) summary

pfam01494
Location:85 → 122

FAD_binding_3; FAD binding domain

pfam12130
Location:929 → 1056

DUF3585; Protein of unknown function (DUF3585)

cd21196
Location:506 → 611

CH_MICAL1; calponin homology (CH) domain found in molecule interacting with CasL protein 1

cl02475
Location:681 → 734

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_063279079.1 → XP_063135149.1 F-actin-monooxygenase MICAL1 isoform X2