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    Prim2 DNA primase subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301323, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Prim2provided by RGD
    Official Full Name
    DNA primase subunit 2provided by RGD
    Primary source
    RGD:631433
    See related
    EnsemblRapid:ENSRNOG00000012486 AllianceGenome:RGD:631433
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pola3
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity and DNA/RNA hybrid binding activity. Predicted to be involved in DNA replication initiation; DNA replication, synthesis of primer; and positive regulation of DNA primase activity. Predicted to be part of alpha DNA polymerase:primase complex. Orthologous to human PRIM2 (DNA primase subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 108.9), Testes (RPKM 101.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prim2 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (43188350..43400482, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (35692376..35904521, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (38535435..38745058)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene SWI5 homologous recombination repair protein, pseudogene 1 Neighboring gene telomerase RNA component interacting RNase, pseudogene 2 Neighboring gene cofilin-2, pseudogene 2 Neighboring gene RAB23, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A mutation in subunit B of the DNA polymerase alpha-primase complex from Novikoff hepatoma cells concomitant with a conformational change and abnormal catalytic properties of the DNA polymerase alpha-primase complex. Popanda O, et al. Mol Carcinog, 2001 Aug. PMID 11536367
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA/RNA hybrid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA/RNA hybrid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA replication, synthesis of primer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication, synthesis of primer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication, synthesis of primer ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA primase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA primase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of alpha DNA polymerase:primase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of alpha DNA polymerase:primase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of alpha DNA polymerase:primase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of alpha DNA polymerase:primase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    DNA primase large subunit
    Names
    DNA polymerase alpha subunit III (primase)
    DNA primase 58 kDa subunit
    DNA primase, p58 subunit
    p58
    primase (DNA) subunit 2
    primase, DNA, polypeptide 2
    NP_001019933.1
    NP_001386112.1
    NP_001386113.1
    XP_006244752.1
    XP_006244753.1
    XP_017451824.1
    XP_038939129.1
    XP_038939130.1
    XP_038939133.1
    XP_038939134.1
    XP_038939135.1
    XP_063122947.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024762.1 → NP_001019933.1  DNA primase large subunit isoform 2

      See identical proteins and their annotated locations for NP_001019933.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097454
      UniProtKB/TrEMBL
      Q4V8C0
      Related
      ENSRNOP00000057197.2, ENSRNOT00000060452.6
      Conserved Domains (2) summary
      cd07322
      Location:28 → 428
      PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL
      COG2219
      Location:22 → 441
      PRI2; Eukaryotic-type DNA primase, large subunit [Replication, recombination and repair]

    2. NM_001399183.1 → NP_001386112.1  DNA primase large subunit isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      O89044
      UniProtKB/TrEMBL
      A6IN89
      Related
      ENSRNOP00000016828.4, ENSRNOT00000016828.10
      Conserved Domains (1) summary
      cd07322
      Location:28 → 451
      PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

    3. NM_001399184.1 → NP_001386113.1  DNA primase large subunit isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      O89044
      UniProtKB/TrEMBL
      A6IN89
      Related
      ENSRNOP00000104632.1, ENSRNOT00000170080.1
      Conserved Domains (1) summary
      cd07322
      Location:28 → 451
      PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      43188350..43400482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596335.3 → XP_017451824.1  DNA primase large subunit isoform X1

      UniProtKB/Swiss-Prot
      O89044
      UniProtKB/TrEMBL
      A6IN89
      Conserved Domains (1) summary
      cd07322
      Location:28 → 451
      PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

    2. XM_006244691.4 → XP_006244753.1  DNA primase large subunit isoform X1

      See identical proteins and their annotated locations for XP_006244753.1

      UniProtKB/Swiss-Prot
      O89044
      UniProtKB/TrEMBL
      A6IN89
      Conserved Domains (1) summary
      cd07322
      Location:28 → 451
      PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

    3. XM_039083201.2 → XP_038939129.1  DNA primase large subunit isoform X1

      UniProtKB/Swiss-Prot
      O89044
      UniProtKB/TrEMBL
      A6IN89
      Conserved Domains (1) summary
      cd07322
      Location:28 → 451
      PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

    4. XM_039083202.2 → XP_038939130.1  DNA primase large subunit isoform X1

      UniProtKB/Swiss-Prot
      O89044
      UniProtKB/TrEMBL
      A6IN89
      Conserved Domains (1) summary
      cd07322
      Location:28 → 451
      PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

    5. XM_006244690.5 → XP_006244752.1  DNA primase large subunit isoform X1

      See identical proteins and their annotated locations for XP_006244752.1

      UniProtKB/Swiss-Prot
      O89044
      UniProtKB/TrEMBL
      A6IN89
      Conserved Domains (1) summary
      cd07322
      Location:28 → 451
      PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

    6. XM_039083205.2 → XP_038939133.1  DNA primase large subunit isoform X2

      Conserved Domains (1) summary
      cd07322
      Location:1 → 327
      PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

    7. XM_063266877.1 → XP_063122947.1  DNA primase large subunit isoform X3

    8. XM_039083206.1 → XP_038939134.1  DNA primase large subunit isoform X4

      Conserved Domains (1) summary
      cd07322
      Location:2 → 221
      PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

    9. XM_039083207.2 → XP_038939135.1  DNA primase large subunit isoform X5

      Conserved Domains (1) summary
      cd07322
      Location:17 → 214
      PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

    RNA

    1. XR_010054582.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O89044.1 GenPept UniProtKB/Swiss-Prot:O89044

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