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    Baz1a bromodomain adjacent to zinc finger domain, 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314126, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Baz1aprovided by RGD
    Official Full Name
    bromodomain adjacent to zinc finger domain, 1Aprovided by RGD
    Primary source
    RGD:1306199
    See related
    EnsemblRapid:ENSRNOG00000006828 AllianceGenome:RGD:1306199
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in several processes, including nucleosome assembly; positive regulation of DNA replication; and regulation of gene expression. Predicted to be located in nucleus and pericentric heterochromatin. Predicted to be part of ACF complex and CHRAC. Predicted to be active in nuclear chromosome. Orthologous to human BAZ1A (bromodomain adjacent to zinc finger domain 1A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 234.1), Spleen (RPKM 151.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Baz1a in Genome Data Viewer
    Location:
    6q23
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (78124872..78247672, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (72389701..72512516, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (75793223..75873854, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene cofilin 2 Neighboring gene uncharacterized LOC108351236 Neighboring gene U6 spliceosomal RNA Neighboring gene RIKEN cDNA 2700097009 gene like Neighboring gene signal recognition particle 54A Neighboring gene uncharacterized LOC134479210 Neighboring gene family with sequence similarity 177, member A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin. Collins N, et al. Nat Genet, 2002 Dec. PMID 12434153
    2. HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins. Poot RA, et al. EMBO J, 2000 Jul 3. PMID 10880450, Free PMC Article
    3. Capturing novel mouse genes encoding chromosomal and other nuclear proteins. Tate P, et al. J Cell Sci, 1998 Sep. PMID 9701556
    4. ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Hargreaves DC, et al. Cell Res, 2011 Mar. PMID 21358755, Free PMC Article
    5. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555636

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ACF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of CHRAC IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CHRAC ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in pericentric heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bromodomain adjacent to zinc finger domain protein 1A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170568.2 → NP_001164039.2  bromodomain adjacent to zinc finger domain protein 1A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      F1M4U9
      Related
      ENSRNOP00000009080.7, ENSRNOT00000009080.9
      Conserved Domains (7) summary
      cd05504
      Location:1419 → 1532
      Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
      PTZ00121
      Location:646 → 793
      PTZ00121; MAEBL; Provisional
      smart00571
      Location:422 → 483
      DDT; domain in different transcription and chromosome remodeling factors
      cd15627
      Location:1147 → 1192
      PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
      pfam10537
      Location:23 → 122
      WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal
      pfam15612
      Location:590 → 635
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:799 → 925
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      78124872..78247672 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261906.1 → XP_063117976.1  bromodomain adjacent to zinc finger domain protein 1A isoform X2

    2. XM_039112223.2 → XP_038968151.1  bromodomain adjacent to zinc finger domain protein 1A isoform X1

      Conserved Domains (7) summary
      cd05504
      Location:1449 → 1562
      Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
      PTZ00121
      Location:646 → 793
      PTZ00121; MAEBL; Provisional
      smart00571
      Location:422 → 483
      DDT; domain in different transcription and chromosome remodeling factors
      cd15627
      Location:1177 → 1222
      PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
      pfam10537
      Location:23 → 122
      WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal
      pfam15612
      Location:590 → 635
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:799 → 925
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    3. XM_063261908.1 → XP_063117978.1  bromodomain adjacent to zinc finger domain protein 1A isoform X3

      UniProtKB/TrEMBL
      A0A8I6G4X5

    4. XM_063261907.1 → XP_063117977.1  bromodomain adjacent to zinc finger domain protein 1A isoform X3

      UniProtKB/TrEMBL
      A0A8I6G4X5
      Related
      ENSRNOP00000079177.1, ENSRNOT00000098593.2

    5. XM_063261905.1 → XP_063117975.1  bromodomain adjacent to zinc finger domain protein 1A isoform X2

    6. XM_039112222.2 → XP_038968150.1  bromodomain adjacent to zinc finger domain protein 1A isoform X1

      Conserved Domains (7) summary
      cd05504
      Location:1449 → 1562
      Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
      PTZ00121
      Location:646 → 793
      PTZ00121; MAEBL; Provisional
      smart00571
      Location:422 → 483
      DDT; domain in different transcription and chromosome remodeling factors
      cd15627
      Location:1177 → 1222
      PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
      pfam10537
      Location:23 → 122
      WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal
      pfam15612
      Location:590 → 635
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:799 → 925
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    7. XM_039112224.2 → XP_038968152.1  bromodomain adjacent to zinc finger domain protein 1A isoform X2

      Conserved Domains (7) summary
      cd05504
      Location:1417 → 1530
      Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
      PTZ00121
      Location:614 → 761
      PTZ00121; MAEBL; Provisional
      smart00571
      Location:422 → 483
      DDT; domain in different transcription and chromosome remodeling factors
      cd15627
      Location:1145 → 1190
      PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
      pfam10537
      Location:23 → 122
      WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal
      pfam15612
      Location:558 → 603
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:767 → 893
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    8. XM_039112225.2 → XP_038968153.1  bromodomain adjacent to zinc finger domain protein 1A isoform X3

      UniProtKB/TrEMBL
      A0A8I6G4X5
      Conserved Domains (7) summary
      cd05504
      Location:1387 → 1500
      Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
      PTZ00121
      Location:614 → 761
      PTZ00121; MAEBL; Provisional
      smart00571
      Location:422 → 483
      DDT; domain in different transcription and chromosome remodeling factors
      cd15627
      Location:1115 → 1160
      PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
      pfam10537
      Location:23 → 122
      WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal
      pfam15612
      Location:558 → 603
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:767 → 893
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    9. XM_063261904.1 → XP_063117974.1  bromodomain adjacent to zinc finger domain protein 1A isoform X2

    10. XM_039112221.1 → XP_038968149.1  bromodomain adjacent to zinc finger domain protein 1A isoform X1

      Conserved Domains (7) summary
      cd05504
      Location:1449 → 1562
      Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
      PTZ00121
      Location:646 → 793
      PTZ00121; MAEBL; Provisional
      smart00571
      Location:422 → 483
      DDT; domain in different transcription and chromosome remodeling factors
      cd15627
      Location:1177 → 1222
      PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
      pfam10537
      Location:23 → 122
      WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal
      pfam15612
      Location:590 → 635
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:799 → 925
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    11. XM_063261909.1 → XP_063117979.1  bromodomain adjacent to zinc finger domain protein 1A isoform X4

    12. XM_039112227.2 → XP_038968155.1  bromodomain adjacent to zinc finger domain protein 1A isoform X6

      UniProtKB/TrEMBL
      A6HBL3
      Conserved Domains (5) summary
      cd05504
      Location:933 → 1046
      Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
      PTZ00121
      Location:130 → 277
      PTZ00121; MAEBL; Provisional
      cd15627
      Location:661 → 706
      PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
      pfam15612
      Location:74 → 119
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:283 → 409
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    13. XM_039112226.2 → XP_038968154.1  bromodomain adjacent to zinc finger domain protein 1A isoform X5

      UniProtKB/TrEMBL
      A6HBL3
      Conserved Domains (5) summary
      cd05504
      Location:965 → 1078
      Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
      PTZ00121
      Location:162 → 309
      PTZ00121; MAEBL; Provisional
      cd15627
      Location:693 → 738
      PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
      pfam15612
      Location:106 → 151
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:315 → 441
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    Nucleotide Protein Strain
    Heading Accession and Version

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