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    H2BP1 H2B histone pseudogene 1 [ Homo sapiens (human) ]

    Gene ID: 337875, updated on 22-Oct-2024

    Summary

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    Official Symbol
    H2BP1provided by HGNC
    Official Full Name
    H2B histone pseudogene 1provided by HGNC
    Primary source
    HGNC:HGNC:20560
    See related
    Ensembl:ENSG00000291123 AllianceGenome:HGNC:20560
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HIST2H2BA
    Summary
    Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is a histone pseudogene found on chromosome 1. [provided by RefSeq, Oct 2015]
    Expression
    Broad expression in ovary (RPKM 2.4), prostate (RPKM 2.1) and 20 other tissues See more
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    Genomic context

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    See H2BP1 in Genome Data Viewer
    Location:
    1p11.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (121107175..121117292, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (121116558..121126675, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (120905993..120916108)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 D4-like Neighboring gene H3 histone pseudogene 4 Neighboring gene uncharacterized LOC100996318 Neighboring gene Fc gamma receptor Ib, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1254 Neighboring gene ribosomal protein L22 pseudogene 6 Neighboring gene family with sequence similarity 72 member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Birth-and-death long-term evolution promotes histone H2B variant diversification in the male germinal cell line. González-Romero R, et al. Mol Biol Evol, 2010 Aug. PMID 20194426
    2. NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. Hublitz P, et al. Genes Dev, 2005 Dec 1. PMID 16322561, Free PMC Article
    3. Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Hughes CM, et al. Mol Cell, 2004 Feb 27. PMID 14992727
    4. The human and mouse replication-dependent histone genes. Marzluff WF, et al. Genomics, 2002 Nov. PMID 12408966
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Other Names

    • histone 2, H2ba
    • histone cluster 2 H2B family member a (pseudogene)
    • histone cluster 2, H2ba (pseudogene)

    Clone Names

    • MGC126029, MGC126031

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027337.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC244453
      Related
      ENST00000430394.3

    2. NR_160942.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC244453
      Related
      ENST00000770023.1

    3. NR_160944.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC244453

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      121107175..121117292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      121116558..121126675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_002621.1: Suppressed sequence

      Description
      NG_002621.1: This RefSeq was permanently suppressed because it is now thought that this gene is a transcribed pseudogene.
    Nucleotide Protein
    Heading Accession and Version

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