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    Tc00.1047053509153.90 dihydrofolate reductase-thymidylate synthase, putative [ Trypanosoma cruzi ]

    Gene ID: 3547029, updated on 23-Nov-2023

    Summary

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    Gene symbol
    Tc00.1047053509153.90
    Gene description
    dihydrofolate reductase-thymidylate synthase, putative
    Locus tag
    Tc00.1047053509153.90
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Trypanosoma cruzi (strain: CL Brener)
    Lineage
    Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum
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    Genomic context

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    See Tc00.1047053509153.90 in Genome Data Viewer
    Location:
    chromosome: Unknown
    Exon count:
    1

    NW_001849530.1Genomic Context describing neighboring genes Neighboring gene exosome-associated protein 3, putative Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_001849530.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Knockout of the dhfr-ts gene in Trypanosoma cruzi generates attenuated parasites able to confer protection against a virulent challenge. Perez Brandan C, et al. PLoS Negl Trop Dis, 2011 Dec. PMID 22180798, Free PMC Article
    2. The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. El-Sayed NM, et al. Science, 2005 Jul 15. PMID 16020725
    3. Comparative genomics of trypanosomatid parasitic protozoa. El-Sayed NM, et al. Science, 2005 Jul 15. PMID 16020724
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study indicates that it is possible to generate genetically attenuated T. cruzi parasites able to confer protection against further T. cruzi infections.
      Title: Knockout of the dhfr-ts gene in Trypanosoma cruzi generates attenuated parasites able to confer protection against a virulent challenge.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Miscellaneous features

    • Loc: 234888-234953 haploid, Esmeraldo-like haplotype
    • Loc: 234954-235949 areas merged during assembly that could not be assigned to a particular haplotype. This can correspond to areas where the two haplotypes were merged or to regions with more than two copies in the genome that were merged during assembly.

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables dihydrofolate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables thymidylate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dTMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tetrahydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dihydrofolate reductase-thymidylate synthase, putative
    XP_815327.1
    • heterozygous, Esmeraldo-like haplotype
      allele of Tc00.1047053420533.9

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NW_001849530.1 Reference assembly

      Range
      234741..236306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_810234.1 → XP_815327.1  dihydrofolate reductase-thymidylate synthase, putative [Trypanosoma cruzi]

      See identical proteins and their annotated locations for XP_815327.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q27793
      UniProtKB/TrEMBL
      A0A2V2WM85, Q4DLS1, Q8T5T9
      Conserved Domains (1) summary
      PTZ00164
      Location:14 → 521
      PTZ00164; bifunctional dihydrofolate reductase-thymidylate synthase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    3INV_A.1
    3INV_B.1
    3IRM_A.1
    3IRM_B.1
    3IRM_C.1
    3IRM_D.1
    3IRN_A.1
    3IRN_B.1
    3IRN_C.1
    3IRN_D.1
    3IRO_A.1
    3IRO_B.1
    3IRO_C.1
    3IRO_D.1
    Q27793.2

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