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    Nbea neurobeachin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361948, updated on 2-Nov-2024

    Summary

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    Symbol
    Nbeaprovided by RGD
    Full Name
    neurobeachinprovided by RGD
    Primary source
    RGD:1562629
    See related
    EnsemblRapid:ENSRNOG00000065312 AllianceGenome:RGD:1562629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562629
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane and synapse organization. Predicted to act upstream of or within hematopoietic stem cell homeostasis and protein localization. Is active in GABA-ergic synapse and cerebellar Golgi cell to granule cell synapse. Is extrinsic component of postsynaptic membrane. Orthologous to human NBEA (neurobeachin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 312.6), Lung (RPKM 150.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nbea in Genome Data Viewer
    Location:
    2q26
    Exon count:
    62
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (141930147..142489172, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (139780021..140338639, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (145011648..145513439, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene doublecortin-like kinase 1 Neighboring gene uncharacterized LOC102552324 Neighboring gene uncharacterized LOC134485917 Neighboring gene uncharacterized LOC134485618 Neighboring gene uncharacterized LOC134485619 Neighboring gene uncharacterized LOC102552834 Neighboring gene uncharacterized LOC102552778 Neighboring gene mab-21 like 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene eukaryotic translation initiation factor 3, subunit I, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nuclear Localization of the Autism Candidate Gene Neurobeachin and Functional Interaction with the NOTCH1 Intracellular Domain Indicate a Role in Regulating Transcription. Tuand K, et al. PLoS One, 2016. PMID 26999814, Free PMC Article
    2. The trafficking proteins Vacuolar Protein Sorting 35 and Neurobeachin interact with the glycine receptor β-subunit. del Pino I, et al. Biochem Biophys Res Commun, 2011 Sep 2. PMID 21821005
    3. Neurobeachin: A protein kinase A-anchoring, beige/Chediak-higashi protein homolog implicated in neuronal membrane traffic. Wang X, et al. J Neurosci, 2000 Dec 1. PMID 11102458, Free PMC Article
    4. Identification of a prognostic 5-Gene expression signature for gastric cancer. Hou JY, et al. J Cancer Res Clin Oncol, 2017 Apr. PMID 28035468

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cerebellar Golgi cell to granule cell synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endomembrane system ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extrinsic component of postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    neurobeachin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427608.1 → NP_001414537.1  neurobeachin

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6AP41
      Related
      ENSRNOP00000089082.2, ENSRNOT00000110270.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      141930147..142489172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282102.1 → XP_063138172.1  neurobeachin isoform X6

    2. XM_063282100.1 → XP_063138170.1  neurobeachin isoform X3

    3. XM_039103982.2 → XP_038959910.1  neurobeachin isoform X5

      UniProtKB/TrEMBL
      A6JVF6
      Conserved Domains (7) summary
      sd00039
      Location:2708 → 2762
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:2276 → 2552
      Beach; Beige/BEACH domain
      pfam06469
      Location:1955 → 2121
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:2147 → 2244
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:469 → 729
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:247 → 394
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:2661 → 2918
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_039103983.2 → XP_038959911.1  neurobeachin isoform X4

      UniProtKB/TrEMBL
      A0A8I6AB61, A6JVF6
      Conserved Domains (7) summary
      sd00039
      Location:2713 → 2767
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:2276 → 2552
      Beach; Beige/BEACH domain
      pfam06469
      Location:1955 → 2121
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:2147 → 2244
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:469 → 729
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:247 → 394
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:2666 → 2923
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_063282099.1 → XP_063138169.1  neurobeachin isoform X2

    6. XM_039103975.2 → XP_038959903.1  neurobeachin isoform X1

      UniProtKB/TrEMBL
      A0A8I6AK76
      Related
      ENSRNOP00000095310.2, ENSRNOT00000106419.2
      Conserved Domains (7) summary
      sd00039
      Location:2734 → 2788
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:2276 → 2573
      Beach; Beige/BEACH domain
      pfam06469
      Location:1955 → 2121
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:2147 → 2244
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:469 → 729
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:247 → 394
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:2687 → 2944
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. XM_063282103.1 → XP_063138173.1  neurobeachin isoform X7

    8. XM_063282104.1 → XP_063138174.1  neurobeachin isoform X8

    RNA

    1. XR_010063625.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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