Shcbp1 SHC binding and spindle associated 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Shcbp1provided by RGD
Official Full Name: SHC binding and spindle associated 1provided by RGD
Primary source: RGD:1590844
See related: EnsemblRapid:ENSRNOG00000053026 AllianceGenome:RGD:1590844
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable SH2 domain binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway and regulation of neural precursor cell proliferation. Predicted to be located in cytoplasm and spindle. Orthologous to human SHCBP1 (SHC binding and spindle associated 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 73.5), Testes (RPKM 63.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.5

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (91373843..91405409)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (84672277..84703843)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (90613826..90642683)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI502109 (e-PCR)
- UniSTS:226237

AW534701 (e-PCR)
- UniSTS:260808

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SHC SH2 domain-binding protein 1

Names: Shc SH2-domain binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399215.1 → NP_001386144.1 SHC SH2 domain-binding protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A0G2K2J0

Related

ENSRNOP00000072261.2, ENSRNOT00000079334.3

Conserved Domains (1) summary

pfam13229
Location:446 → 546

Beta_helix; Right handed beta helix region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

91373843..91405409

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095271.2 → XP_038951199.1 SHC SH2 domain-binding protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I5ZZD8

Related

ENSRNOP00000083446.1, ENSRNOT00000094192.2

Conserved Domains (1) summary

pfam13229
Location:403 → 527

Beta_helix; Right handed beta helix region