Tgm3 transglutaminase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tgm3provided by RGD
Official Full Name: transglutaminase 3provided by RGD
Primary source: RGD:1561831
See related: EnsemblRapid:ENSRNOG00000006753 AllianceGenome:RGD:1561831
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TGE; TG(E); RGD1561831
Summary: Predicted to enable calcium ion binding activity; protein-glutamine gamma-glutamyltransferase activity; and structural molecule activity. Predicted to be involved in keratinocyte differentiation and peptide cross-linking. Predicted to be located in cytoplasm. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to be part of protein-containing complex. Orthologous to human TGM3 (transglutaminase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 105.7), Adrenal (RPKM 44.2) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (137681809..137717219)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (117228661..117264078)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (122544783..122580836)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

L10385 (e-PCR)
- UniSTS:159033

BI281152 (e-PCR)
- UniSTS:249407

AU047681 (e-PCR)
- UniSTS:110269

d3rat162 (e-PCR)
- UniSTS:121822

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables catalytic activity	ISO Inferred from Sequence Orthology more info
enables protein-glutamine gamma-glutamyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-glutamine gamma-glutamyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-glutamine gamma-glutamyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables structural molecule activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in keratinization	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in peptide cross-linking	ISO Inferred from Sequence Orthology more info
involved_in peptide cross-linking	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in extrinsic component of cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein-glutamine gamma-glutamyltransferase E

Names: TGase E; TGase-3; glutamine gamma-glutamyltransferase E; transglutaminase 3, E polypeptide; transglutaminase E

NP_001102429.1

EC 2.3.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108959.1 → NP_001102429.1 protein-glutamine gamma-glutamyltransferase E

See identical proteins and their annotated locations for NP_001102429.1

Status: PROVISIONAL

Source sequence(s)

CH473949

UniProtKB/Swiss-Prot

D4A5U3

Related

ENSRNOP00000059160.1, ENSRNOT00000063828.4

Conserved Domains (3) summary

smart00460
Location:265 → 357

TGc; Transglutaminase/protease-like homologues

pfam00868
Location:5 → 117

Transglut_N; Transglutaminase family

pfam00927
Location:595 → 691

Transglut_C; Transglutaminase family, C-terminal ig like domain