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    sptan1.L spectrin, alpha, non-erythrocytic 1 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 373718, updated on 4-Nov-2024

    Summary

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    Official Symbol
    sptan1.L
    Official Full Name
    spectrin, alpha, non-erythrocytic 1 L homeolog
    Primary source
    Xenbase:XB-GENE-6252716
    Locus tag
    XELAEV_18002795mg
    See related
    EnsemblRapid:ENSXLAG00005019251 AllianceGenome:Xenbase:XB-GENE-6252716
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    neas; sptan1; sptan1-a; sptan1-b; Xen alpha 2
    Summary
    Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 11 and developmental and epileptic encephalopathy 5. Orthologous to human SPTAN1 (spectrin alpha, non-erythrocytic 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See sptan1.L in Genome Data Viewer
    Location:
    chromosome: 8L
    Exon count:
    57
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8L NC_054385.1 (10311948..10341147, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016694827.1 (262040..291368, complement)

    Chromosome 8L - NC_054385.1Genomic Context describing neighboring genes Neighboring gene SET nuclear proto-oncogene L homeolog Neighboring gene dynein 2 intermediate chain 2 L homeolog Neighboring gene GLE1, RNA export mediator L homeolog Neighboring gene outer dense fiber of sperm tails 2 L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Changes in the expression of alpha-fodrin during embryonic development of Xenopus laevis. Giebelhaus DH, et al. J Cell Biol, 1987 Aug. PMID 3040772, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    General protein information

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    Preferred Names
    spectrin alpha chain, non-erythrocytic 1
    Names
    (alpha)ii-spectrin
    alpha-spectrin
    spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      10311948..10341147 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041573148.1 → XP_041429082.1  spectrin alpha chain, non-erythrocytic 1 isoform X5

      UniProtKB/TrEMBL
      A0A8J1LHS5, A0A974H5K6
      Conserved Domains (4) summary
      smart00150
      Location:1665 → 1765
      SPEC; Spectrin repeats
      cd11808
      Location:971 → 1023
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:2352 → 2420
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:679 → 890
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    2. XM_041573147.1 → XP_041429081.1  spectrin alpha chain, non-erythrocytic 1 isoform X4

      UniProtKB/TrEMBL
      A0A8J1LIB2, A0A974H5K6
      Related
      ENSXLAP00005056881.1, ENSXLAT00005058190.1
      Conserved Domains (4) summary
      smart00150
      Location:1640 → 1740
      SPEC; Spectrin repeats
      cd11808
      Location:971 → 1023
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:2306 → 2374
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:679 → 890
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    3. XM_041573145.1 → XP_041429079.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

      UniProtKB/TrEMBL
      A0A8J1LJ22, A0A974H5K6
      Related
      ENSXLAP00005057000.1, ENSXLAT00005058332.1
      Conserved Domains (4) summary
      smart00150
      Location:1645 → 1745
      SPEC; Spectrin repeats
      cd11808
      Location:971 → 1023
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:2311 → 2379
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:679 → 890
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    4. XM_041573144.1 → XP_041429078.1  spectrin alpha chain, non-erythrocytic 1 isoform X2

      UniProtKB/TrEMBL
      A0A8J1LHN6, A0A974H5K6
      Related
      ENSXLAP00005056806.1, ENSXLAT00005058102.1
      Conserved Domains (4) summary
      smart00150
      Location:1660 → 1760
      SPEC; Spectrin repeats
      cd11808
      Location:971 → 1023
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:2326 → 2394
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:679 → 890
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    5. XM_041573143.1 → XP_041429077.1  spectrin alpha chain, non-erythrocytic 1 isoform X1

      UniProtKB/TrEMBL
      A0A8J1LHR9, A0A974H5K6
      Related
      ENSXLAP00005056980.1, ENSXLAT00005058309.1
      Conserved Domains (4) summary
      smart00150
      Location:1665 → 1765
      SPEC; Spectrin repeats
      cd11808
      Location:971 → 1023
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:2331 → 2399
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:679 → 890
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    Nucleotide Protein Strain
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