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    PCLO piccolo presynaptic cytomatrix protein [ Gallus gallus (chicken) ]

    Gene ID: 395319, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PCLOprovided by CGNC
    Official Full Name
    piccolo presynaptic cytomatrix proteinprovided by CGNC
    Primary source
    CGNC:49263
    See related
    Ensembl:ENSGALG00010006261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    ACZ
    Orthologs
    human mouse all
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    Genomic context

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    See PCLO in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (9939054..10269735)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (10070173..10398099)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene semaphorin 3A Neighboring gene semaphorin 3E Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 1 Neighboring gene uncharacterized LOC112532984 Neighboring gene uncharacterized LOC112532986 Neighboring gene uncharacterized LOC107057089

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin. Wang X, et al. J Cell Biol, 1999 Oct 4. PMID 10508862, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables structural constituent of presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in presynaptic active zone assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein localization to synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoskeleton of presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein piccolo
    Names
    aczonin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396406.1 → NP_001383335.1  protein piccolo

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000012, Y19187
      UniProtKB/TrEMBL
      A0A8V0XXL2
      Related
      ENSGALP00010008778.1, ENSGALT00010014914.1
      Conserved Domains (8) summary
      PTZ00121
      Location:1023 → 1451
      PTZ00121; MAEBL; Provisional
      cd04031
      Location:4691 → 4825
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03247
      Location:232 → 862
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4507 → 4585
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      PTZ00108
      Location:1383 → 1636
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      cl14603
      Location:5067 → 5192
      C2; C2 domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      9939054..10269735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040665411.2 → XP_040521345.1  protein piccolo isoform X1

      UniProtKB/TrEMBL
      A0A8V0XXL2
      Conserved Domains (8) summary
      PTZ00121
      Location:1023 → 1451
      PTZ00121; MAEBL; Provisional
      cd04031
      Location:4691 → 4825
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03247
      Location:232 → 862
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4507 → 4585
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      PTZ00108
      Location:1383 → 1636
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      cl14603
      Location:5066 → 5191
      C2; C2 domain

    2. XM_040665421.2 → XP_040521355.1  protein piccolo isoform X3

      UniProtKB/TrEMBL
      A0A8V0XXL2
      Conserved Domains (8) summary
      PTZ00121
      Location:1023 → 1451
      PTZ00121; MAEBL; Provisional
      cd04031
      Location:4691 → 4825
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03247
      Location:232 → 862
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4507 → 4585
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      PTZ00108
      Location:1383 → 1636
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      cl14603
      Location:5031 → 5156
      C2; C2 domain

    3. XM_040665430.2 → XP_040521364.1  protein piccolo isoform X4

      UniProtKB/TrEMBL
      A0A8V0XQ04, A0A8V0XXL2
      Related
      ENSGALP00010008781.1, ENSGALT00010014920.1
      Conserved Domains (8) summary
      PTZ00121
      Location:1023 → 1451
      PTZ00121; MAEBL; Provisional
      cd04031
      Location:4691 → 4825
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03247
      Location:232 → 862
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4507 → 4585
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      PTZ00108
      Location:1383 → 1636
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      cl14603
      Location:5006 → 5131
      C2; C2 domain

    4. XM_040665417.2 → XP_040521351.1  protein piccolo isoform X2

      UniProtKB/TrEMBL
      A0A8V0XXL2
      Conserved Domains (8) summary
      PTZ00121
      Location:1023 → 1451
      PTZ00121; MAEBL; Provisional
      cd04031
      Location:4691 → 4816
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03247
      Location:232 → 862
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4507 → 4585
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      PTZ00108
      Location:1383 → 1636
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      cl14603
      Location:5058 → 5183
      C2; C2 domain

    5. XM_040665439.2 → XP_040521373.1  protein piccolo isoform X5

      UniProtKB/TrEMBL
      A0A8V0XXL2, A0A8V0XXL7
      Related
      ENSGALP00010008783.1, ENSGALT00010014924.1
      Conserved Domains (8) summary
      PTZ00121
      Location:1023 → 1451
      PTZ00121; MAEBL; Provisional
      cd04031
      Location:4691 → 4816
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03247
      Location:232 → 862
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4507 → 4585
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      PTZ00108
      Location:1383 → 1636
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      cl14603
      Location:4997 → 5122
      C2; C2 domain

    6. XM_040665448.2 → XP_040521382.1  protein piccolo isoform X6

      UniProtKB/TrEMBL
      A0A8V0XXL2
      Conserved Domains (6) summary
      PTZ00121
      Location:1023 → 1451
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:232 → 862
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4507 → 4585
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      PTZ00108
      Location:1383 → 1636
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo

    7. XM_040665459.2 → XP_040521393.1  protein piccolo isoform X7

      UniProtKB/TrEMBL
      A0A8V0XXL2
      Conserved Domains (6) summary
      PTZ00121
      Location:1023 → 1451
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:232 → 862
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4507 → 4579
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      PTZ00108
      Location:1383 → 1636
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      10070173..10398099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040657390.2 → XP_040513324.1  protein piccolo isoform X1

      UniProtKB/TrEMBL
      A0A8V0XXL2
      Conserved Domains (8) summary
      PTZ00121
      Location:1023 → 1450
      PTZ00121; MAEBL; Provisional
      cd04031
      Location:4690 → 4824
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03247
      Location:232 → 862
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4506 → 4584
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      PTZ00108
      Location:1382 → 1635
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      cl14603
      Location:5065 → 5190
      C2; C2 domain

    2. XM_040657392.2 → XP_040513326.1  protein piccolo isoform X3

      UniProtKB/TrEMBL
      A0A8V0XXL2
      Conserved Domains (8) summary
      PTZ00121
      Location:1023 → 1450
      PTZ00121; MAEBL; Provisional
      cd04031
      Location:4690 → 4824
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03247
      Location:232 → 862
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4506 → 4584
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      PTZ00108
      Location:1382 → 1635
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      cl14603
      Location:5030 → 5155
      C2; C2 domain

    3. XM_040657393.2 → XP_040513327.1  protein piccolo isoform X4

      UniProtKB/TrEMBL
      A0A8V0XXL2
      Conserved Domains (8) summary
      PTZ00121
      Location:1023 → 1450
      PTZ00121; MAEBL; Provisional
      cd04031
      Location:4690 → 4824
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03247
      Location:232 → 862
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4506 → 4584
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      PTZ00108
      Location:1382 → 1635
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      cl14603
      Location:5005 → 5130
      C2; C2 domain

    4. XM_040657391.2 → XP_040513325.1  protein piccolo isoform X2

      UniProtKB/TrEMBL
      A0A8V0XXL2
      Conserved Domains (8) summary
      PTZ00121
      Location:1023 → 1450
      PTZ00121; MAEBL; Provisional
      cd04031
      Location:4690 → 4815
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03247
      Location:232 → 862
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4506 → 4584
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      PTZ00108
      Location:1382 → 1635
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      cl14603
      Location:5057 → 5182
      C2; C2 domain

    5. XM_040657394.2 → XP_040513328.1  protein piccolo isoform X5

      UniProtKB/TrEMBL
      A0A8V0XXL2
      Conserved Domains (8) summary
      PTZ00121
      Location:1023 → 1450
      PTZ00121; MAEBL; Provisional
      cd04031
      Location:4690 → 4815
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03247
      Location:232 → 862
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4506 → 4584
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      PTZ00108
      Location:1382 → 1635
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      cl14603
      Location:4996 → 5121
      C2; C2 domain

    6. XM_040657395.2 → XP_040513329.1  protein piccolo isoform X6

      UniProtKB/TrEMBL
      A0A8V0XXL2
      Conserved Domains (6) summary
      PTZ00121
      Location:1023 → 1450
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:232 → 862
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4506 → 4584
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      PTZ00108
      Location:1382 → 1635
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo

    7. XM_040657396.2 → XP_040513330.1  protein piccolo isoform X7

      UniProtKB/TrEMBL
      A0A8V0XXL2
      Conserved Domains (6) summary
      PTZ00121
      Location:1023 → 1450
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:232 → 862
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4506 → 4578
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      PTZ00108
      Location:1382 → 1635
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9PU36.1 GenPept UniProtKB/Swiss-Prot:Q9PU36

    Gene LinkOut

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