SFRP2 secreted frizzled related protein 2 [Gallus gallus (chicken)] - Gene

Summary

Symbol: SFRP2provided by CGNC
Full Name: secreted frizzled related protein 2provided by CGNC
Primary source: CGNC:7021
See related: Ensembl:ENSGALG00010014880
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: SFRP-2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	4	NC_052535.1 (19529587..19533860, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	4	NC_052576.1 (19598599..19602873, complement)

Chromosome 4 - NC_052535.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

sFRP2 may play an active role in embryogenesis, especially in development of the neural system, eyes, muscles and limbs
Title: Investigation of mRNA expression for secreted frizzled-related protein 2 (sFRP2) in chick embryos.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables Wnt-protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in non-canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: secreted frizzled-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204773.2 → NP_990104.2 secreted frizzled-related protein 2 precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000071

UniProtKB/Swiss-Prot

Q9IA96

UniProtKB/TrEMBL

A0A8V0YQ13

Related

ENSGALP00010020759.1, ENSGALT00010035802.1

Conserved Domains (2) summary

cd07446
Location:33 → 160

CRD_SFRP2; Cysteine-rich domain of the secreted frizzled-related protein 2 (SFRP2), a regulator of Wnt activity

cd03580
Location:166 → 292

NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

19529587..19533860 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

19598599..19602873 complement

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GenBank, FASTA, Sequence Viewer (Graphics)