LGALS2 galectin 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LGALS2provided by HGNC
Official Full Name: galectin 2provided by HGNC
Primary source: HGNC:HGNC:6562
See related: Ensembl:ENSG00000100079 MIM:150571; AllianceGenome:HGNC:6562
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HL14
Summary: The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008]
Expression: Biased expression in gall bladder (RPKM 133.8), small intestine (RPKM 81.3) and 7 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 22q13.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (37570248..37580087, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (38031510..38041349, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (37966255..37976094, complement)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulatory T Cell Apoptosis during Preeclampsia May Be Prevented by Gal-2.
Title: Regulatory T Cell Apoptosis during Preeclampsia May Be Prevented by Gal-2.
Gene polymorphisms of LGALS2, LGALS3 and LGALS9 in patients with rheumatoid arthritis.
Title: Gene polymorphisms of LGALS2, LGALS3 and LGALS9 in patients with rheumatoid arthritis.
Syndecan 4, galectin 2, and death receptor 3 (DR3) as novel proteins in pathophysiology of preeclampsia.
Title: Syndecan 4, galectin 2, and death receptor 3 (DR3) as novel proteins in pathophysiology of preeclampsia.
Genome-wide CRISPR screen identifies LGALS2 as an oxidative stress-responsive gene with an inhibitory function on colon tumor growth.
Title: Genome-wide CRISPR screen identifies LGALS2 as an oxidative stress-responsive gene with an inhibitory function on colon tumor growth.
Placental Galectin-2 Expression in Gestational Diabetes: A Systematic, Histological Analysis.
Title: Placental Galectin-2 Expression in Gestational Diabetes: A Systematic, Histological Analysis.
Study observed decreased methylation at the DHCR24 locus in offspring of women with active pregnancy eating disorders (ED) and increased methylation at the LGALS2 locus in offspring of women with past ED compared to controls.
Title: Maternal eating disorders affect offspring cord blood DNA methylation: a prospective study.
Data show that lactose binding to galectin-2 (Gal-2) stabilizes the lectin's conformation.
Title: Human galectin-2 interacts with carbohydrates and peptides non-classically: new insight from X-ray crystallography and hemagglutination.
Gal-3 was significantly downregulated only in the extravillous trophoblast of intrauterine growth restriction ( IUGR) placentas. In contrast, expressions of gal-2 and gal-13 were downregulated in both villous and extravillous trophoblast cells of IUGR placentas.
Title: Placental Expression Patterns of Galectin-1, Galectin-2, Galectin-3 and Galectin-13 in Cases of Intrauterine Growth Restriction (IUGR).
Galectin-1 was undetectable in normal and ulcerative colitis colonic epithelium, while galectin-2, galectin-3, and galectin-4 were strongly expressed.
Title: Immunohistochemical Studies on Galectin Expression in Colectomised Patients with Ulcerative Colitis.
Galectin-2 binding to different circulating human monocyte subsets depends on monocyte surface expression levels of CD14. It skews human macrophages to a M1-like proinflammatory phenotype.
Title: Galectin-2 induces a proinflammatory, anti-arteriogenic phenotype in monocytes and macrophages.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Myocardial infarction, susceptibility to MedGen: C1832662 OMIM: 608446 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH71441 (e-PCR)
- UniSTS:11038

RH93754 (e-PCR)
- UniSTS:91837

GDB:452630 (e-PCR)
- UniSTS:157399

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables galactoside binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of galectin complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: galectin-2

Names: S-Lac lectin 2; beta-galactoside-binding lectin L-14-II; gal-2; lactose-binding lectin 2; lectin, galactoside-binding, soluble, 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012096.1 RefSeqGene

Range

4931..14770

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_006498.3 → NP_006489.1 galectin-2

See identical proteins and their annotated locations for NP_006489.1

Status: REVIEWED

Source sequence(s)

AL022315, BC059782, CD701729

Consensus CDS

CCDS13950.1

UniProtKB/Swiss-Prot

P05162, Q6FGY4

UniProtKB/TrEMBL

Q6PIT8

Related

ENSP00000215886.4, ENST00000215886.6

Conserved Domains (1) summary

cd00070
Location:11 → 129

GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...