ISL2 ISL LIM homeobox 2 [Gallus gallus (chicken)] - Gene

Summary

Symbol: ISL2provided by CGNC
Full Name: ISL LIM homeobox 2provided by CGNC
Primary source: CGNC:49781
See related: Ensembl:ENSGALG00010024053
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: ISLET-2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	10	NC_052541.1 (3370211..3375446, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	10	NC_052582.1 (3246493..3249510, complement)

Chromosome 10 - NC_052541.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in axonogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neuron fate specification	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: insulin gene enhancer protein ISL-2

Names: domesticus (clone 1.6 kB) islet-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001396684.1 → NP_001383613.1 insulin gene enhancer protein ISL-2

Status: VALIDATED

Description

Transcript Variant: This variant (1) has 6 exons. The fifth exon is the long variant.

Source sequence(s)

JAENSK010000245

UniProtKB/TrEMBL

A0A8V0ZXL3

Related

ENSGALP00010035621.1, ENSGALT00010058602.1

Conserved Domains (3) summary

cd09366
Location:27 → 81

LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family

cd09471
Location:89 → 143

LIM2_Isl2; The second LIM domain of Isl2

smart00389
Location:187 → 243

HOX; Homeodomain
NM_001396685.1 → NP_001383614.1 insulin gene enhancer protein ISL-2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has five exons. It lacks the first intron found in the other variant. The fourth exon is the short variant.

Source sequence(s)

JAENSK010000245

Conserved Domains (3) summary

cd09366
Location:167 → 221

LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family

smart00389
Location:327 → 383

HOX; Homeodomain

cl02475
Location:229 → 283

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

3370211..3375446 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015279027.4 → XP_015134513.1 insulin gene enhancer protein ISL-2 isoform X1

Conserved Domains (3) summary

cd09366
Location:27 → 81

LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family

smart00389
Location:187 → 243

HOX; Homeodomain

cl02475
Location:89 → 143

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_040706981.2 → XP_040562915.1 insulin gene enhancer protein ISL-2 isoform X3

Conserved Domains (3) summary

cd09366
Location:167 → 221

LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family

smart00389
Location:327 → 383

HOX; Homeodomain

cl02475
Location:229 → 283

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_015279024.4 → XP_015134510.2 insulin gene enhancer protein ISL-2 isoform X2

Conserved Domains (3) summary

cd09366
Location:167 → 221

LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family

cd09471
Location:229 → 283

LIM2_Isl2; The second LIM domain of Isl2

smart00389
Location:327 → 383

HOX; Homeodomain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

3246493..3249510 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040680535.2 → XP_040536469.1 insulin gene enhancer protein ISL-2 isoform X1

Conserved Domains (3) summary

cd09366
Location:27 → 81

LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family

smart00389
Location:187 → 243

HOX; Homeodomain

cl02475
Location:89 → 143

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers