U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    B2M beta-2-microglobulin [ Sus scrofa (pig) ]

    Gene ID: 397033, updated on 16-Nov-2023

    Summary

    Go to the top of the page Help
    Gene symbol
    B2M
    Gene description
    beta-2-microglobulin
    See related
    Ensembl:ENSSSCG00000051899
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Ubiquitous expression in spleen (RPKM 5169.6), lung (RPKM 4618.3) and 8 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See B2M in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (126865767..126878501, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 1 NC_010443.4 (141437043..141449779, complement)

    Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110261204 Neighboring gene beta-2-microglobulin Neighboring gene uncharacterized LOC110261210 Neighboring gene SPG11 vesicle trafficking associated, spatacsin

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. [Analyzing secondary structure of beta2 microglobulin in Escherichia coli with circular dichroism spectrum]. Gao F, et al. Wei Sheng Wu Xue Bao, 2009 Dec. PMID 20222444
    2. Isolation of a clone for pig beta 2-microglobulin cDNA. Milland J, et al. Immunogenetics, 1993. PMID 8406623
    3. Development of a new set of reference genes for normalization of real-time RT-PCR data of porcine backfat and longissimus dorsi muscle, and evaluation with PPARGC1A. Erkens T, et al. BMC Biotechnol, 2006 Oct 9. PMID 17026777, Free PMC Article
    4. Selection of reference genes for gene expression studies in pig tissues using SYBR green qPCR. Nygard AB, et al. BMC Mol Biol, 2007 Aug 15. PMID 17697375, Free PMC Article
    5. Evaluation and characterization of a porcine small intestine cDNA library: analysis of 839 clones. Wintero AK, et al. Mamm Genome, 1996 Jul. PMID 8672129

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. B2M contains alpha-helix, beta-sheet, turn, and random coil.
      Title: [Analyzing secondary structure of beta2 microglobulin in Escherichia coli with circular dichroism spectrum].
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptide antigen assembly with MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MHC class I protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    beta-2-microglobulin
    Names
    lactollin

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213978.1 → NP_999143.1  beta-2-microglobulin precursor

      See identical proteins and their annotated locations for NP_999143.1

      Status: PROVISIONAL

      Source sequence(s)
      L13854
      UniProtKB/Swiss-Prot
      Q07717, Q8WN08
      UniProtKB/TrEMBL
      A0A5S6FYV9, B2NJ26
      Related
      ENSSSCP00000063329.1, ENSSSCT00000084189.2
      Conserved Domains (1) summary
      cd05770
      Location:24 → 115
      IgC_beta2m; Class I major histocompatibility complex (MHC) beta2-microglobulin

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

      Range
      126865767..126878501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.