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    ebf3.L EBF transcription factor 3 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 399125, updated on 4-Nov-2024

    Summary

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    Official Symbol
    ebf3.L
    Official Full Name
    EBF transcription factor 3 L homeolog
    Primary source
    Xenbase:XB-GENE-962547
    Locus tag
    XELAEV_18034571mg
    See related
    EnsemblRapid:ENSXLAG00005011098 AllianceGenome:Xenbase:XB-GENE-962547
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    oe2; coe3; ebf3; Xcoe3; Xebf3; xebf-3
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and metal ion binding activity. Predicted to act upstream of or within positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in anatomical system; pharyngeal arch; and primary germ layer. Human ortholog(s) of this gene implicated in hypotonia, ataxia, and delayed development syndrome. Orthologous to human EBF3 (EBF transcription factor 3). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: partial on reference assembly
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    Genomic context

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    See ebf3.L in Genome Data Viewer
    Location:
    chromosome: 7L
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7L NC_054383.1 (17009881..17143196)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7L NC_030736.1 (17046031..17179419)

    Chromosome 7L - NC_054383.1Genomic Context describing neighboring genes Neighboring gene uncharacterized protein C10orf143-like Neighboring gene uncharacterized LOC121395341 Neighboring gene O-6-methylguanine-DNA methyltransferase L homeolog Neighboring gene uncharacterized LOC108696115

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Xebf3 is a regulator of neuronal differentiation during primary neurogenesis in Xenopus. Pozzoli O, et al. Dev Biol, 2001 May 15. PMID 11336510
    2. Gene expression analysis of developing cell groups in the pretectal region of Xenopus laevis. Morona R, et al. J Comp Neurol, 2017 Mar 1. PMID 27539385
    3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor COE3
    Names
    OE-2
    early B cell factor 3 L homeolog
    olf-1/EBF-like 2
    xOE-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001090332.1 → NP_001083801.1  transcription factor COE3

      See identical proteins and their annotated locations for NP_001083801.1

      Status: PROVISIONAL

      Source sequence(s)
      AF040994
      UniProtKB/Swiss-Prot
      O73742
      UniProtKB/TrEMBL
      A0A974CE56, A0A974CEG5, B7ZRR5
      Related
      ENSXLAP00005032649.1, ENSXLAT00005033441.1
      Conserved Domains (3) summary
      cd01175
      Location:264 → 348
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:349 → 392
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      17009881..17143196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O73742.2 GenPept UniProtKB/Swiss-Prot:O73742

    Gene LinkOut

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