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    COX5A Cytochrome c oxidase subunit 5A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41432, updated on 18-Sep-2024

    Summary

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    Official Symbol
    COX5Aprovided by FlyBase
    Official Full Name
    Cytochrome c oxidase subunit 5Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0019624
    Locus tag
    Dmel_CG14724
    See related
    AllianceGenome:FB:FBgn0019624
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14724; cova; CoVa; COX; COX-5A; cox5A; Cox5a; COX5a; COXA; COXA_DROME; Dmel\CG14724; mito; Q94514; tend; Va
    Summary
    Predicted to enable cytochrome-c oxidase activity. Involved in positive regulation of cell cycle. Located in mitochondrion. Is expressed in adult head; adult heart; organism; and spermatozoon. Used to study cytochrome-c oxidase deficiency disease. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX5A (cytochrome c oxidase subunit 5A). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See COX5A in Genome Data Viewer
    Location:
    86F9-86F9; 3-51 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11819359..11820299)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7645081..7646021)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Histamine-gated chloride channel subunit 1 Neighboring gene SET domain binding factor Neighboring gene Chloride channel-a Neighboring gene glorund Neighboring gene Kynurenine aminotransferase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of mitochondrial organization and function in the Drosophila blastoderm embryo. Chowdhary S, et al. Sci Rep, 2017 Jul 14. PMID 28710464, Free PMC Article
    2. Selective propagation of functional mitochondrial DNA during oogenesis restricts the transmission of a deleterious mitochondrial variant. Hill JH, et al. Nat Genet, 2014 Apr. PMID 24614072, Free PMC Article
    3. Mitochondrial dynamics regulates Drosophila intestinal stem cell differentiation. Deng H, et al. Cell Death Discov, 2018. PMID 30062062, Free PMC Article
    4. Expression profiling of attenuated mitochondrial function identifies retrograde signals in Drosophila. Freije WA, et al. G3 (Bethesda), 2012 Aug. PMID 22908033, Free PMC Article
    5. Glorund, a Drosophila hnRNP F/H homolog, is an ovarian repressor of nanos translation. Kalifa Y, et al. Dev Cell, 2006 Mar. PMID 16516833

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 5A
    Names
    CG14724-PA
    CG14724-PB
    CG14724-PC
    CG14724-PD
    COX5A-PA
    COX5A-PB
    COX5A-PC
    COX5A-PD
    complex IV
    cytochrome c oxidase
    cytochrome c oxidase Va
    cytochrome c oxidase Va, mt precursor
    cytochrome c oxidase polypeptide Va
    cytochrome c oxidase subunit Va
    cytochrome c oxidase subunit Va preprotein
    cytochrome oxidase Va
    cytochrome oxidase subunit Va
    cytochrome-c oxidase subunit Va
    subunit 5A
    subunit Va
    subunit Va of complex IV
    tenured

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11819359..11820299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057869.4 → NP_477217.1  cytochrome c oxidase subunit 5A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477217.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53XG7, Q94514, Q9VGH4
      UniProtKB/TrEMBL
      A0A0B4KFT0
      Related
      FBpp0081947
      Conserved Domains (1) summary
      cd00923
      Location:33 → 136
      Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    2. NM_169436.3 → NP_731641.1  cytochrome c oxidase subunit 5A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731641.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53XG7, Q94514, Q9VGH4
      UniProtKB/TrEMBL
      A0A0B4KFT0
      Related
      FBpp0081948
      Conserved Domains (1) summary
      cd00923
      Location:33 → 136
      Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    3. NM_001316557.1 → NP_001303486.1  cytochrome c oxidase subunit 5A, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53XG7, Q94514, Q9VGH4
      UniProtKB/TrEMBL
      A0A0B4KFT0
      Conserved Domains (1) summary
      cd00923
      Location:33 → 136
      Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    4. NM_001275559.1 → NP_001262488.1  cytochrome c oxidase subunit 5A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262488.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53XG7, Q94514, Q9VGH4
      UniProtKB/TrEMBL
      A0A0B4KFT0
      Conserved Domains (1) summary
      cd00923
      Location:33 → 136
      Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFT0 A0A0B4KFT0
    Q94514.2 Q94514

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