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    GOLGA8B golgin A8 family member B [ Homo sapiens (human) ]

    Gene ID: 440270, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GOLGA8Bprovided by HGNC
    Official Full Name
    golgin A8 family member Bprovided by HGNC
    Primary source
    HGNC:HGNC:31973
    See related
    Ensembl:ENSG00000215252 MIM:609619; AllianceGenome:HGNC:31973
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GOLGA5
    Summary
    Predicted to be involved in Golgi organization. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 78.1), testis (RPKM 47.6) and 24 other tissues See more
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    Genomic context

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    See GOLGA8B in Genome Data Viewer
    Location:
    15q14
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (34525095..34583651, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (32330791..32389340, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (34817296..34875852, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene fascin actin-bundling protein 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6287 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6288 Neighboring gene dynamin 1 pseudogene 5 Neighboring gene microRNA 1233-2 Neighboring gene amyloid beta precursor protein binding family A member 2 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:34861909-34862858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6289 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6290 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6291 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:34876125-34876626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:34876627-34877127 Neighboring gene MPRA-validated peak2294 silencer Neighboring gene Sharpr-MPRA regulatory region 9988 Neighboring gene uncharacterized LOC124903462 Neighboring gene Sharpr-MPRA regulatory region 12620 Neighboring gene long intergenic non-protein coding RNA 2252

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma. Li Z, et al. Clin Sci (Lond), 2022 Jun 17. PMID 35593117
    2. Human autoantibodies to a novel Golgi protein golgin-67: high similarity with golgin-95/gm 130 autoantigen. Eystathioy T, et al. J Autoimmun, 2000 Mar. PMID 10677249
    3. Identification and characterization of a novel Golgi protein, golgin-67. Jakymiw A, et al. J Biol Chem, 2000 Feb 11. PMID 10660574
    4. A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14. Solouki AM, et al. Nat Genet, 2010 Oct. PMID 20835239, Free PMC Article
    5. Analysis of the DNA sequence and duplication history of human chromosome 15. Zody MC, et al. Nature, 2006 Mar 30. PMID 16572171

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma.
      Title: Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0855

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in Golgi cis cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi cisterna membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cis-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    golgin subfamily A member 8B
    Names
    golgi autoantigen, golgin subfamily a, 8B
    golgin-67

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001023567.5 → NP_001018861.3  golgin subfamily A member 8B

      See identical proteins and their annotated locations for NP_001018861.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
      Source sequence(s)
      AC027139
      Consensus CDS
      CCDS45211.1
      UniProtKB/Swiss-Prot
      A6NLZ2, A8MQT2, Q2M3S9
      UniProtKB/TrEMBL
      B7ZKM1
      Related
      ENSP00000507830.1, ENST00000683415.1
      Conserved Domains (2) summary
      pfam01496
      Location:268 → 322
      V_ATPase_I; V-type ATPase 116kDa subunit family
      pfam15070
      Location:218 → 593
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

    RNA

    1. NR_027410.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate upstream promoter and additional 5' exons and retains an intron, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC027139
      Related
      ENST00000569100.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      34525095..34583651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      32330791..32389340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8MQT2.2 GenPept UniProtKB/Swiss-Prot:A8MQT2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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