for foraging [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: forprovided by FlyBase
Official Full Name: foragingprovided by FlyBase
Primary source: FLYBASE:FBgn0000721
Locus tag: Dmel_CG10033
See related: AllianceGenome:FB:FBgn0000721
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 142251_at; anon-WO0140519.260; anon-WO02059370.47; BcDNA:GM08338; CG10033; dg2; Dg2; DG2; Dmel\CG10033; For; FOR/PKG; l(2)06860; PKG; Pkg2; PKG2; Pkg24A
Summary: Enables cGMP-dependent protein kinase activity. Involved in several processes, including larval feeding behavior; learning or memory; and motor neuron axon guidance. Located in cytosol and plasma membrane. Is expressed in several structures, including ectoderm anlage; extended germ band embryo; head; nervous system; and presumptive embryonic/larval system. Used to study epilepsy. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human PRKG1 (protein kinase cGMP-dependent 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 24A2-24A4; 2-10 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (3622074..3656953, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (3622074..3656953, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Drosophila melanogaster foraging gene affects social networks.
Title: The Drosophila melanogaster foraging gene affects social networks.
The foraging gene affects alcohol sensitivity, metabolism and memory in Drosophila.
Title: The foraging gene affects alcohol sensitivity, metabolism and memory in Drosophila.
Expression of the foraging gene in adult Drosophila melanogaster.
Title: Expression of the foraging gene in adult Drosophila melanogaster.
A cGMP-dependent protein kinase, encoded by the Drosophila foraging gene, regulates neurotransmission through changes in synaptic structure and function.
Title: A cGMP-dependent protein kinase, encoded by the Drosophila foraging gene, regulates neurotransmission through changes in synaptic structure and function.
The Drosophila foraging gene plays a vital role at the start of metamorphosis for subsequent adult emergence.
Title: The Drosophila foraging gene plays a vital role at the start of metamorphosis for subsequent adult emergence.
Environmental influences on for-mediated oviposition decisions in Drosophila melanogaster.
Title: Environmental influences on for-mediated oviposition decisions in Drosophila melanogaster.
Drosophila melanogaster foraging regulates a nociceptive-like escape behavior through a developmentally plastic sensory circuit.
Title: Drosophila melanogaster foraging regulates a nociceptive-like escape behavior through a developmentally plastic sensory circuit.
FOR plays a critical role in coupling synaptic vesicle exocytosis and endocytosis, thereby balancing these two components to maintain sustained neurotransmission.
Title: Distinct functions of a cGMP-dependent protein kinase in nerve terminal growth and synaptic vesicle cycling.
Polymorphism in the foraging gene confers protection during low oxygen stress at the expense of longevity and a decline in locomotor activity with age in D. melanogaster, which suggests a novel role for the PKG pathway in healthy aging and senescence.
Title: Natural polymorphism in protein kinase G modulates functional senescence in Drosophilamelanogaster.
Our results refine the spatial expression responsible for foraging's associated phenotypes, as well as the sub-regions of the locus responsible for their expression. foraging's pleiotropy arises at least in part from the individual contributions of its four promoters
Title: Pleiotropy of the Drosophila melanogaster foraging gene on larval feeding-related traits.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cGMP-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cGMP-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in feeding behavior	TAS Traceable Author Statement more info	PubMed
involved_in habituation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval feeding behavior	TAS Traceable Author Statement more info	PubMed
involved_in larval locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Toll signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein kinase A signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of response to food	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to sucrose	IDA Inferred from Direct Assay more info	PubMed
involved_in short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: foraging

Names: CG10033-PA; CG10033-PC; CG10033-PD; CG10033-PE; CG10033-PG; CG10033-PH; CG10033-PI; CG10033-PJ; CG10033-PK; CG10033-PL; CG10033-PM; CG10033-PN; CG10033-PO; for-PA; for-PC; for-PD; for-PE; for-PG; for-PH; for-PI; for-PJ; for-PK; for-PL; for-PM; for-PN; for-PO

NP_001014464.1

EC 2.7.11.1

EC 2.7.11.12

NP_001162858.1

EC 2.7.11.1

EC 2.7.11.12

NP_001334731.1

EC 2.7.11.1

EC 2.7.11.12

NP_001356892.1

EC 2.7.11.1

EC 2.7.11.12

NP_001356896.1

EC 2.7.11.1

EC 2.7.11.12

NP_001356955.1

EC 2.7.11.1

EC 2.7.11.12

NP_477487.1

EC 2.7.11.1

EC 2.7.11.12

NP_477489.1

EC 2.7.11.1

EC 2.7.11.12

NP_477490.1

EC 2.7.11.1

EC 2.7.11.12

NP_599146.1

EC 2.7.11.1

EC 2.7.11.12

NP_995626.1

EC 2.7.11.1

EC 2.7.11.12

NP_995628.1

EC 2.7.11.1

EC 2.7.11.12

NP_995629.1

EC 2.7.11.1

EC 2.7.11.12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

3622074..3656953 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_205904.2 → NP_995626.1 foraging, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995626.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V042, Q03043, Q24304, Q9I7Q1, Q9VQT2

UniProtKB/TrEMBL

E1U3G1

Conserved Domains (5) summary

cd12085
Location:385 → 432

DD_cGKI-alpha; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I alpha

smart00220
Location:778 → 1036

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG0664
Location:632 → 753

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:638 → 754

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:783 → 1043

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_001369953.1 → NP_001356892.1 foraging, isoform M [Drosophila melanogaster]

Status: REVIEWED

Conserved Domains (2) summary

cd00038
Location:118 → 234

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:263 → 523

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_058139.4 → NP_477487.1 foraging, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477487.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V042, Q03043, Q24304, Q9I7Q1, Q9VQT2

UniProtKB/TrEMBL

E1U3G1

Related

FBpp0088350

Conserved Domains (5) summary

cd12085
Location:385 → 432

DD_cGKI-alpha; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I alpha

smart00220
Location:778 → 1036

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG0664
Location:632 → 753

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:638 → 754

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:783 → 1043

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_001369954.1 → NP_001356896.1 foraging, isoform N [Drosophila melanogaster]

Status: REVIEWED

Conserved Domains (2) summary

cd00038
Location:118 → 234

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:263 → 523

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_205906.2 → NP_995628.1 foraging, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995628.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V042, Q03043, Q24304, Q9I7Q1, Q9VQT2

UniProtKB/TrEMBL

E1U3G1

Conserved Domains (5) summary

cd12085
Location:385 → 432

DD_cGKI-alpha; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I alpha

smart00220
Location:778 → 1036

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG0664
Location:632 → 753

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:638 → 754

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:783 → 1043

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_001347740.1 → NP_001334731.1 foraging, isoform L [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1W5Q0S1, E1U3F9
NM_001369955.1 → NP_001356955.1 foraging, isoform O [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4D6K344

Conserved Domains (2) summary

cd00038
Location:21 → 137

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:166 → 426

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_001014464.2 → NP_001014464.1 foraging, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014464.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V044, A4V046, P32023, Q0E8U1, Q24302, Q24303, Q9I7Q0, Q9I7Q2

UniProtKB/TrEMBL

E1U3G0

Conserved Domains (4) summary

smart00220
Location:624 → 882

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG0664
Location:478 → 599

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:484 → 600

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:629 → 889

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_058141.4 → NP_477489.1 foraging, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477489.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHR9, E1U3G2

Related

FBpp0088353

Conserved Domains (4) summary

smart00220
Location:584 → 842

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG0664
Location:438 → 559

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:444 → 560

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:589 → 849

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_205907.2 → NP_995629.1 foraging, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995629.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHR9, E1U3G2

Conserved Domains (4) summary

smart00220
Location:584 → 842

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG0664
Location:438 → 559

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:444 → 560

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:589 → 849

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_134319.4 → NP_599146.1 foraging, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_599146.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHR9, E1U3G2

Related

FBpp0088354

Conserved Domains (4) summary

smart00220
Location:584 → 842

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG0664
Location:438 → 559

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:444 → 560

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:589 → 849

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_058142.4 → NP_477490.1 foraging, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477490.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V044, A4V046, P32023, Q0E8U1, Q24302, Q24303, Q9I7Q0, Q9I7Q2

UniProtKB/TrEMBL

E1U3G0

Related

FBpp0088352

Conserved Domains (4) summary

smart00220
Location:624 → 882

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG0664
Location:478 → 599

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:484 → 600

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:629 → 889

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_001169387.2 → NP_001162858.1 foraging, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162858.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHR9, E1U3G2

Conserved Domains (4) summary

smart00220
Location:584 → 842

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG0664
Location:438 → 559

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:444 → 560

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:589 → 849

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)