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    ADIPOR1 adiponectin receptor 1 [ Homo sapiens (human) ]

    Gene ID: 51094, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ADIPOR1provided by HGNC
    Official Full Name
    adiponectin receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:24040
    See related
    Ensembl:ENSG00000159346 MIM:607945; AllianceGenome:HGNC:24040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGI45; PAQR1; ACDCR1; CGI-45; TESBP1A
    Summary
    This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]
    Expression
    Ubiquitous expression in bone marrow (RPKM 58.7), placenta (RPKM 45.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ADIPOR1 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (202940825..202958572, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (202203545..202221296, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (202909953..202927700, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:202853813-202854312 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2337 Neighboring gene RAB interacting factor Neighboring gene kelch like family member 12 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 59 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:202897631-202898132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:202898133-202898632 Neighboring gene Sharpr-MPRA regulatory region 11793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1712 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1713 Neighboring gene Sharpr-MPRA regulatory region 11869 Neighboring gene cytochrome b5 reductase 1 Neighboring gene MGAT4 family member F, pseudogene Neighboring gene ribosomal protein S20 pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Adiponectin receptor expression in human malignant tissues. Chou SH, et al. Horm Cancer, 2010 Jun. PMID 21761356, Free PMC Article
    2. Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors. Neumeier M, et al. Biochem Biophys Res Commun, 2005 Sep 2. PMID 16023994
    3. No conclusive evidence for association of polymorphisms in the adiponectin receptor 1 gene, AdipoR1, with common obesity. Beckers S, et al. Endocrine, 2013 Feb. PMID 22767440
    4. Differential expression of novel adiponectin receptor-1 transcripts in skeletal muscle of subjects with normal glucose tolerance and type 2 diabetes. Ashwal R, et al. Diabetes, 2011 Mar. PMID 21289205, Free PMC Article
    5. Novel Adiponectin Receptor Agonist Inhibits Cholangiocarcinoma via Adenosine Monophosphate-activated Protein Kinase. Bui KC, et al. Curr Med Chem, 2024. PMID 38361349

    See all (239) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel Adiponectin Receptor Agonist Inhibits Cholangiocarcinoma via Adenosine Monophosphate-activated Protein Kinase.
      Title: Novel Adiponectin Receptor Agonist Inhibits Cholangiocarcinoma via Adenosine Monophosphate-activated Protein Kinase.
    2. Overexpression of salusin-beta downregulates adipoR1 expression to prevent fatty acid oxidation in HepG2 cells.
      Title: Overexpression of salusin‑β downregulates adipoR1 expression to prevent fatty acid oxidation in HepG2 cells.
    3. Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings.
      Title: Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings.
    4. Circulating adiponectin levels, expression of adiponectin receptors, and methylation of adiponectin gene promoter in relation to Alzheimer's disease.
      Title: Circulating adiponectin levels, expression of adiponectin receptors, and methylation of adiponectin gene promoter in relation to Alzheimer's disease.
    5. AdipoR1 Regulates Ionizing Radiation-Induced Ferroptosis in HCC cells through Nrf2/xCT Pathway.
      Title: AdipoR1 Regulates Ionizing Radiation-Induced Ferroptosis in HCC cells through Nrf2/xCT Pathway.
    6. Circulating Adiponectin and Its Association with Metabolic Traits and Type 2 Diabetes: Gene-Diet Interactions Focusing on Selected Gene Variants and at the Genome-Wide Level in High-Cardiovascular Risk Mediterranean Subjects.
      Title: Circulating Adiponectin and Its Association with Metabolic Traits and Type 2 Diabetes: Gene-Diet Interactions Focusing on Selected Gene Variants and at the Genome-Wide Level in High-Cardiovascular Risk Mediterranean Subjects.
    7. From diabetes to renal aging: the therapeutic potential of adiponectin.
      Title: From diabetes to renal aging: the therapeutic potential of adiponectin.
    8. Human adiponectin receptor AdipoR1 assumes closed and open structures.
      Title: Human adiponectin receptor AdipoR1 assumes closed and open structures.
    9. The expression and relationship of AdipoR1/R2 in gastric intestinal metaplasia.
      Title: The expression and relationship of AdipoR1/R2 in gastric intestinal metaplasia.
    10. Adiponectin is associated with cardio-metabolic traits in Mexican children.
      Title: Adiponectin is associated with cardio-metabolic traits in Mexican children.
    Submit: New GeneRIF Correction See all GeneRIFs (196)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ25385, FLJ42464

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables adipokinetic hormone receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adiponectin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adiponectin-activated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adiponectin-activated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in hormone-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in leptin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of non-canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    adiponectin receptor protein 1
    Names
    progestin and adipoQ receptor family member 1
    progestin and adipoQ receptor family member I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052860.1 RefSeqGene

      Range
      5261..22741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001290553.2 → NP_001277482.1  adiponectin receptor protein 1

      See identical proteins and their annotated locations for NP_001277482.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as R1T2) has an alternate 5' UTR exon, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AI251444, BC010743, DA523648
      Consensus CDS
      CCDS1430.1
      UniProtKB/Swiss-Prot
      B3KMB0, Q53HS7, Q53YY6, Q96A54, Q9Y360
      Conserved Domains (1) summary
      pfam03006
      Location:129 → 352
      HlyIII; Haemolysin-III related

    2. NM_001290557.1 → NP_001277486.1  adiponectin receptor protein 1

      See identical proteins and their annotated locations for NP_001277486.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as R1T3) has an additional internal exon in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AC096632, AI251444, BC010743, BI597715
      Consensus CDS
      CCDS1430.1
      UniProtKB/Swiss-Prot
      B3KMB0, Q53HS7, Q53YY6, Q96A54, Q9Y360
      Conserved Domains (1) summary
      pfam03006
      Location:129 → 352
      HlyIII; Haemolysin-III related

    3. NM_001290629.1 → NP_001277558.1  adiponectin receptor protein 1

      See identical proteins and their annotated locations for NP_001277558.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as R1T4) has an alternate 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AI251444, BC010743, BI597715, BX461217
      Consensus CDS
      CCDS1430.1
      UniProtKB/Swiss-Prot
      B3KMB0, Q53HS7, Q53YY6, Q96A54, Q9Y360
      Conserved Domains (1) summary
      pfam03006
      Location:129 → 352
      HlyIII; Haemolysin-III related

    4. NM_015999.6 → NP_057083.2  adiponectin receptor protein 1

      See identical proteins and their annotated locations for NP_057083.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as R1T1) is a predominant transcript. All variants encode the same protein.
      Source sequence(s)
      AC096632, AI251444, BC010743
      Consensus CDS
      CCDS1430.1
      UniProtKB/Swiss-Prot
      B3KMB0, Q53HS7, Q53YY6, Q96A54, Q9Y360
      Related
      ENSP00000341785.5, ENST00000340990.10
      Conserved Domains (1) summary
      pfam03006
      Location:129 → 352
      HlyIII; Haemolysin-III related

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      202940825..202958572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421959.1 → XP_047277915.1  adiponectin receptor protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B3KMB0, Q53HS7, Q53YY6, Q96A54, Q9Y360

    2. XM_024447427.2 → XP_024303195.1  adiponectin receptor protein 1 isoform X2

      Conserved Domains (1) summary
      pfam03006
      Location:11 → 197
      HlyIII; Haemolysin-III related

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      202203545..202221296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336880.1 → XP_054192855.1  adiponectin receptor protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B3KMB0, Q53HS7, Q53YY6, Q96A54, Q9Y360

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_046083.1: Suppressed sequence

      Description
      NR_046083.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96A54.1 GenPept UniProtKB/Swiss-Prot:Q96A54

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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