U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    PTOV1 PTOV1 extended AT-hook containing adaptor protein [ Homo sapiens (human) ]

    Gene ID: 53635, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PTOV1provided by HGNC
    Official Full Name
    PTOV1 extended AT-hook containing adaptor proteinprovided by HGNC
    Primary source
    HGNC:HGNC:9632
    See related
    Ensembl:ENSG00000104960 MIM:610195; AllianceGenome:HGNC:9632
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACID2; PTOV-1
    Summary
    This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
    Expression
    Ubiquitous expression in testis (RPKM 29.1), adrenal (RPKM 28.7) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PTOV1 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49850705..49860742)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52850843..52860879)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50353962..50363999)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10936 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50316420-50317226 Neighboring gene fuzzy planar cell polarity protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14958 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:50321502-50321668 Neighboring gene mediator complex subunit 25 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50337816-50338316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50338317-50338817 Neighboring gene microRNA 6800 Neighboring gene PTOV1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14959 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10938 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14960 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14961 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14963 Neighboring gene PTOV1 antisense RNA 2 Neighboring gene microRNA 4749 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50368723-50369505 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50369506-50370288 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50370289-50371070 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50373269-50373916 Neighboring gene polynucleotide kinase 3'-phosphatase Neighboring gene AKT1 substrate 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50379233-50380192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14965 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:50381153-50382112 Neighboring gene TBC1 domain family member 17

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Overexpression of prostate tumor overexpressed 1 correlates with tumor progression and predicts poor prognosis in breast cancer. Lei F, et al. BMC Cancer, 2014 Jun 19. PMID 24947166, Free PMC Article
    2. Prostate tumor overexpressed-1, in conjunction with human papillomavirus status, predicts outcome in early-stage human laryngeal squamous cell carcinoma. Yang L, et al. Oncotarget, 2016 May 31. PMID 26992242, Free PMC Article
    3. PTOV1 is overexpressed in human high-grade malignant tumors. Fernández S, et al. Virchows Arch, 2011 Mar. PMID 21181414
    4. The role of prostate tumor overexpressed 1 in cancer progression. Cánovas V, et al. Oncotarget, 2017 Feb 14. PMID 28029646, Free PMC Article
    5. Overexpressed PTOV1 associates with tumorigenesis and progression of esophageal squamous cell carcinoma. Li R, et al. Tumour Biol, 2017 Jun. PMID 28651486

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the acquisition of resistance in laryngeal cancer seems to be related to PTOV1
      Title: Autophagy inhibition as a promising therapeutic target for laryngeal cancer.
    2. PTOV1 interaction with translation complexes and its direct binding to ALDH1A1 and CCNG2 promoters found here reveal the PTOV1 capacity to modulate the expression of critical genes at multiple levels in aggressive cancers.
      Title: A novel DNA-binding motif in prostate tumor overexpressed-1 (PTOV1) required for the expression of ALDH1A1 and CCNG2 in cancer cells.
    3. PTOV1 and PIN1 interact and exert oncogenic role in MDA-MB-231 cells by sharing the similar expression profile at transcriptional and translational level which can be a promising hub for therapeutic target.
      Title: Knockdown of PTOV1 and PIN1 exhibit common phenotypic anti-cancer effects in MDA-MB-231 cells.
    4. this study revealed PTOV1 as a poor prognosis factor for NSCLC patients, and targeting PTOV1 can be a strategy to increase chemosensitivity in NSCLC.
      Title: Depleting PTOV1 sensitizes non-small cell lung cancer cells to chemotherapy through attenuating cancer stem cell traits.
    5. The combination of PTOV1 expression level and HPV status provides more prognostic information compared with HPV status alone in early-stage human laryngeal squamous cell carcinoma.
      Title: Prostate tumor overexpressed-1, in conjunction with human papillomavirus status, predicts outcome in early-stage human laryngeal squamous cell carcinoma.
    6. Studies indicate that the number of binding partners and associated cellular functions has increased and helped to identify prostate-tumor-overexpressed-1 (PTOV1) as regulator of gene expression at transcription and translation levels.
      Title: The role of prostate tumor overexpressed 1 in cancer progression.
    7. this study takes the lead to demonstrate that the overexpressed PTOV1 plays a vital role in the tumorigenesis and progression of esophageal squamous cell carcinoma, and it is potentially a valuable prognostic predicator and new chemotherapeutic target for esophageal squamous cell carcinoma
      Title: Overexpressed PTOV1 associates with tumorigenesis and progression of esophageal squamous cell carcinoma.
    8. All the study samples showed a considerable decrease in PTOV1 expression in prostate cancer and HGPIN compared to morphologically normal glands.
      Title: [Estimation of the diagnostic potential of APOD, PTOV1, and EPHA4 for prostatic neoplasms].
    9. High PTOV1 expression was associated with invasive urothelial carcinoma.
      Title: Prostate tumor overexpressed 1 expression in invasive urothelial carcinoma.
    10. PTOV1 overexpression is associated with poor survival outcomes of nasopharyngeal carcinoma patients.
      Title: Prostate Tumor Overexpressed 1 (PTOV1) Is a Novel Prognostic Marker for Nasopharyngeal Carcinoma Progression and Poor Survival Outcomes.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC71475, DKFZp586I111

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    prostate tumor-overexpressed gene 1 protein
    Names
    activator interaction domain-containing protein 2
    prostate tumor overexpressed 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050666.1 RefSeqGene

      Range
      6892..16901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001305105.2 → NP_001292034.1  prostate tumor-overexpressed gene 1 protein isoform 1

      See identical proteins and their annotated locations for NP_001292034.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1). This transcript contains splicing in the 3' UTR that makes it a candidate for nonsense-mediated mRNA decay (NMD). However, this protein is thought to be valid.
      Source sequence(s)
      AA582677, AC018766, AJ617480
      Consensus CDS
      CCDS12782.1
      UniProtKB/Swiss-Prot
      Q6UXX7, Q86YD1, Q96BU3, Q9HBN4, Q9NYL1
      Related
      ENSP00000469128.1, ENST00000599732.5
      Conserved Domains (1) summary
      pfam11232
      Location:93 → 238
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2

    2. NM_001305108.2 → NP_001292037.1  prostate tumor-overexpressed gene 1 protein isoform 2

      See identical proteins and their annotated locations for NP_001292037.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 5' region, initiates translation at an alternate start codon and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) has distinct N- and C-termini and is shorter than isoform 1.
      Source sequence(s)
      AC018766
      Consensus CDS
      CCDS82379.1
      UniProtKB/TrEMBL
      A0A0C4DGR2
      Related
      ENSP00000471458.1, ENST00000600603.5
      Conserved Domains (1) summary
      pfam11232
      Location:61 → 206
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2

    3. NM_001364745.2 → NP_001351674.1  prostate tumor-overexpressed gene 1 protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC018766
      Consensus CDS
      CCDS92668.1
      UniProtKB/TrEMBL
      M0QY25
      Related
      ENSP00000469541.1, ENST00000601638.5
      Conserved Domains (1) summary
      pfam11232
      Location:61 → 206
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2

    4. NM_001364747.2 → NP_001351676.1  prostate tumor-overexpressed gene 1 protein isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC018766
      Conserved Domains (2) summary
      pfam11232
      Location:108 → 253
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      cl26247
      Location:1 → 156
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    5. NM_001364748.2 → NP_001351677.1  prostate tumor-overexpressed gene 1 protein isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC018766
      Conserved Domains (1) summary
      pfam11232
      Location:117 → 258
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2

    6. NM_001364749.2 → NP_001351678.1  prostate tumor-overexpressed gene 1 protein isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC018766
      Conserved Domains (2) summary
      pfam11232
      Location:108 → 253
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      cl26247
      Location:1 → 156
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    7. NM_001364750.2 → NP_001351679.1  prostate tumor-overexpressed gene 1 protein isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC018766
      Related
      ENST00000598325.5
      Conserved Domains (1) summary
      pfam11232
      Location:117 → 258
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2

    8. NM_001394010.1 → NP_001380939.1  prostate tumor-overexpressed gene 1 protein isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC018766
      Consensus CDS
      CCDS12782.1
      UniProtKB/Swiss-Prot
      Q6UXX7, Q86YD1, Q96BU3, Q9HBN4, Q9NYL1
      Related
      ENSP00000375717.1, ENST00000391842.6
      Conserved Domains (1) summary
      pfam11232
      Location:93 → 238
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2

    9. NM_017432.5 → NP_059128.2  prostate tumor-overexpressed gene 1 protein isoform 1

      See identical proteins and their annotated locations for NP_059128.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). This transcript contains splicing in the 3' UTR that makes it a candidate for nonsense-mediated mRNA decay (NMD). However, this protein is thought to be valid.
      Source sequence(s)
      AA582677, AC018766, BC042921
      Consensus CDS
      CCDS12782.1
      UniProtKB/Swiss-Prot
      Q6UXX7, Q86YD1, Q96BU3, Q9HBN4, Q9NYL1
      Related
      ENSP00000472816.1, ENST00000601675.5
      Conserved Domains (1) summary
      pfam11232
      Location:93 → 238
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2

    RNA

    1. NR_130963.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses alternate splice sites in two exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC018766
      Related
      ENST00000601612.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      49850705..49860742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438940.1 → XP_047294896.1  prostate tumor-overexpressed gene 1 protein isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      52850843..52860879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321224.1 → XP_054177199.1  prostate tumor-overexpressed gene 1 protein isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86YD1.1 GenPept UniProtKB/Swiss-Prot:Q86YD1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools