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    CTNNB1 catenin beta 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 539003, updated on 12-Oct-2024

    Summary

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    Official Symbol
    CTNNB1provided by VGNC
    Official Full Name
    catenin beta 1provided by VGNC
    Primary source
    VGNC:VGNC:27802
    See related
    BGD:BT22729; Ensembl:ENSBTAG00000016420
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CTNNB1 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (13799069..13847827)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC132343484 Neighboring gene unc-51 like kinase 4 Neighboring gene trafficking kinesin protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The β-catenin signaling pathway stimulates bovine herpesvirus 1 productive infection. Zhu L, et al. Virology, 2017 Jan. PMID 27788397, Free PMC Article
    2. β-Catenin, a Transcription Factor Activated by Canonical Wnt Signaling, Is Expressed in Sensory Neurons of Calves Latently Infected with Bovine Herpesvirus 1. Liu Y, et al. J Virol, 2016 Jan 6. PMID 26739046, Free PMC Article
    3. Trenbolone enhances myogenic differentiation by enhancing β-catenin signaling in muscle-derived stem cells of cattle. Zhao JX, et al. Domest Anim Endocrinol, 2011 May. PMID 21402455, Free PMC Article
    4. {beta}-Catenin regulates airway smooth muscle contraction. Jansen SR, et al. Am J Physiol Lung Cell Mol Physiol, 2010 Aug. PMID 20472712
    5. Wnt/beta-catenin signaling stimulates chondrogenic and inhibits adipogenic differentiation of pericytes: potential relevance to vascular disease? Kirton JP, et al. Circ Res, 2007 Sep 14. PMID 17673669

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bovine herpesvirus 1 transiently increased beta-catenin protein levels in bovine kidney cells, but not in rabbit skin cells.
      Title: The β-catenin signaling pathway stimulates bovine herpesvirus 1 productive infection.
    2. These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.
      Title: Protein kinase B is required for follicle-stimulating hormone mediated beta-catenin accumulation and estradiol production in granulosa cells of cattle.
    3. beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves.
      Title: β-Catenin, a Transcription Factor Activated by Canonical Wnt Signaling, Is Expressed in Sensory Neurons of Calves Latently Infected with Bovine Herpesvirus 1.
    4. These data demonstrate for the first time that FSH regulates CTNNB1 protein and WNT2 mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT signaling in ovarian steroidogenesis and follicular growth of cattle.
      Title: Follicle-stimulating hormone regulation of estradiol production: possible involvement of WNT2 and β-catenin in bovine granulosa cells.
    5. These data provide evidence that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin-targeted genes and myogenesis in the muscle-derived stem cells of cattle.
      Title: Trenbolone enhances myogenic differentiation by enhancing β-catenin signaling in muscle-derived stem cells of cattle.
    6. that beta-catenin is a plasma membrane-associated protein in airway smooth muscle that regulates active tension development, presumably by stabilizing cell-cell contacts and thereby supporting force transmission between neighboring cells.
      Title: {beta}-Catenin regulates airway smooth muscle contraction.
    7. cAMP/PKA regulation of GSK3beta/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.
      Title: Convergence of 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A and glycogen synthase kinase-3beta/beta-catenin signaling in corpus luteum progesterone synthesis.
    8. This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin.
      Title: Beta-catenin localization and timing of early development of bovine embryos obtained from oocytes matured in the presence of follicle stimulating hormone.
    9. TGF-beta3 induces the chondrogenic differentiation of pericytes by inducing Wnt/beta-catenin signaling and T-cell factor-induced gene transcription.
      Title: Wnt/beta-catenin signaling stimulates chondrogenic and inhibits adipogenic differentiation of pericytes: potential relevance to vascular disease?
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC139922

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables alpha-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of catenin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    catenin beta-1
    Names
    beta-catenin
    catenin (cadherin-associated protein), beta 1, 88kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076141.1 → NP_001069609.1  catenin beta-1

      See identical proteins and their annotated locations for NP_001069609.1

      Status: PROVISIONAL

      Source sequence(s)
      BC119949
      UniProtKB/Swiss-Prot
      A7E3R2, Q0VCX4
      UniProtKB/TrEMBL
      A0AAF6Z2K7
      Related
      ENSBTAP00000021838.5, ENSBTAT00000021838.6
      Conserved Domains (4) summary
      smart00185
      Location:350 → 390
      ARM; Armadillo/beta-catenin-like repeats
      COG5064
      Location:142 → 431
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:402 → 427
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:583 → 622
      Arm; Armadillo/beta-catenin-like repeat

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      13799069..13847827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005222525.5 → XP_005222582.1  catenin beta-1 isoform X1

      See identical proteins and their annotated locations for XP_005222582.1

      UniProtKB/Swiss-Prot
      A7E3R2, Q0VCX4
      UniProtKB/TrEMBL
      A0AAF6Z2K7
      Conserved Domains (4) summary
      smart00185
      Location:350 → 390
      ARM; Armadillo/beta-catenin-like repeats
      COG5064
      Location:142 → 431
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:402 → 427
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:583 → 622
      Arm; Armadillo/beta-catenin-like repeat

    2. XM_059879801.1 → XP_059735784.1  catenin beta-1 isoform X1

      UniProtKB/Swiss-Prot
      A7E3R2, Q0VCX4

    3. XM_005222524.5 → XP_005222581.1  catenin beta-1 isoform X1

      See identical proteins and their annotated locations for XP_005222581.1

      UniProtKB/Swiss-Prot
      A7E3R2, Q0VCX4
      UniProtKB/TrEMBL
      A0AAF6Z2K7
      Conserved Domains (4) summary
      smart00185
      Location:350 → 390
      ARM; Armadillo/beta-catenin-like repeats
      COG5064
      Location:142 → 431
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:402 → 427
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:583 → 622
      Arm; Armadillo/beta-catenin-like repeat

    4. XM_059879803.1 → XP_059735786.1  catenin beta-1 isoform X1

      UniProtKB/Swiss-Prot
      A7E3R2, Q0VCX4

    5. XM_024982935.2 → XP_024838703.1  catenin beta-1 isoform X1

      UniProtKB/Swiss-Prot
      A7E3R2, Q0VCX4
      UniProtKB/TrEMBL
      A0AAF6Z2K7
      Conserved Domains (4) summary
      smart00185
      Location:350 → 390
      ARM; Armadillo/beta-catenin-like repeats
      COG5064
      Location:142 → 431
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:402 → 427
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:583 → 622
      Arm; Armadillo/beta-catenin-like repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VCX4.1 GenPept UniProtKB/Swiss-Prot:Q0VCX4

    Gene LinkOut

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