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    NAT10 N-acetyltransferase 10 [ Homo sapiens (human) ]

    Gene ID: 55226, updated on 14-Nov-2024

    Summary

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    Official Symbol
    NAT10provided by HGNC
    Official Full Name
    N-acetyltransferase 10provided by HGNC
    Primary source
    HGNC:HGNC:29830
    See related
    Ensembl:ENSG00000135372 MIM:609221; AllianceGenome:HGNC:29830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALP; Kre33; NET43
    Summary
    The protein encoded by this gene is an RNA cytidine acetyltransferase involved in histone acetylation, tRNA acetylation, the biosynthesis of 18S rRNA, and the enhancement of nuclear architecture and chromatin organization. [provided by RefSeq, Oct 2016]
    Expression
    Ubiquitous expression in lymph node (RPKM 12.6), testis (RPKM 11.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NAT10 in Genome Data Viewer
    Location:
    11p13
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (34105629..34146908)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (34242631..34283911)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (34127176..34168455)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929918 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:34072933-34073132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4591 Neighboring gene uncharacterized LOC124902660 Neighboring gene cell cycle associated protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4593 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34171467-34171996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4595 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34177103-34177604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34181310-34181810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34181811-34182311 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34195130-34196052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34196053-34196973 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34204513-34205014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34205015-34205514 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:34208067-34208830 Neighboring gene ankyrin repeat and BTB domain containing 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:34213997-34214182 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:34214651-34215536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34215704-34216532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:34226078-34226684 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:34255548-34256072 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:34260669-34261168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34261893-34262392 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:34263557-34264756 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:34264949-34265620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4600 Neighboring gene Sharpr-MPRA regulatory region 14004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34306064-34306564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34306565-34307065 Neighboring gene MPRA-validated peak1251 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4601 Neighboring gene MMADHC pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3251 Neighboring gene CRISPRi-validated cis-regulatory element chr11.1764 Neighboring gene MPRA-validated peak1252 silencer Neighboring gene CIR1 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac(4)C acetylation of KIF23 mRNA. Jin C, et al. J Exp Clin Cancer Res, 2022 Dec 15. PMID 36522719, Free PMC Article
    2. NAT10 promotes the tumorigenesis and progression of laryngeal squamous cell carcinoma through ac4C modification of FOXM1 mRNA. Li Z, et al. Cancer Biol Ther, 2023 Dec 31. PMID 37948132, Free PMC Article
    3. Autoacetylation of NAT10 is critical for its function in rRNA transcription activation. Cai S, et al. Biochem Biophys Res Commun, 2017 Jan 29. PMID 27993683
    4. NAT10 is upregulated in hepatocellular carcinoma and enhances mutant p53 activity. Li Q, et al. BMC Cancer, 2017 Aug 31. PMID 28859621, Free PMC Article
    5. NAT10-mediated N4-acetylcytidine mRNA modification regulates self-renewal in human embryonic stem cells. Liu R, et al. Nucleic Acids Res, 2023 Sep 8. PMID 37497776, Free PMC Article

    See all (241) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-acetyltransferase 10 is implicated in the pathogenesis of cycling T cell-mediated autoimmune and inflammatory disorders in mice.
      Title: N-acetyltransferase 10 is implicated in the pathogenesis of cycling T cell-mediated autoimmune and inflammatory disorders in mice.
    2. NAT10-mediated ac[4]C acetylation of TFRC promotes sepsis-induced pulmonary injury through regulating ferroptosis.
      Title: NAT10-mediated ac(4)C acetylation of TFRC promotes sepsis-induced pulmonary injury through regulating ferroptosis.
    3. Lactylation of NAT10 promotes N[4]-acetylcytidine modification on tRNA[Ser-CGA-1-1] to boost oncogenic DNA virus KSHV reactivation.
      Title: Lactylation of NAT10 promotes N(4)-acetylcytidine modification on tRNA(Ser-CGA-1-1) to boost oncogenic DNA virus KSHV reactivation.
    4. NAT10 Promotes Prostate Cancer Growth and Metastasis by Acetylating mRNAs of HMGA1 and KRT8.
      Title: NAT10 Promotes Prostate Cancer Growth and Metastasis by Acetylating mRNAs of HMGA1 and KRT8.
    5. NAT10 promotes synovial aggression by increasing the stability and translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis.
      Title: NAT10 promotes synovial aggression by increasing the stability and translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis.
    6. NAT10 Overexpression Promotes Tumorigenesis and Epithelial-Mesenchymal Transition Through AKT Pathway in Gastric Cancer.
      Title: NAT10 Overexpression Promotes Tumorigenesis and Epithelial-Mesenchymal Transition Through AKT Pathway in Gastric Cancer.
    7. N-acetyltransferase 10 facilitates tumorigenesis of diffuse large B-cell lymphoma by regulating AMPK/mTOR signalling through N4-acetylcytidine modification of SLC30A9.
      Title: N-acetyltransferase 10 facilitates tumorigenesis of diffuse large B-cell lymphoma by regulating AMPK/mTOR signalling through N4-acetylcytidine modification of SLC30A9.
    8. Dissecting the oncogenic properties of essential RNA-modifying enzymes: a focus on NAT10.
      Title: Dissecting the oncogenic properties of essential RNA-modifying enzymes: a focus on NAT10.
    9. NAT10-mediated mRNA N4-acetylcytidine modification of MDR1 and BCRP promotes breast cancer progression.
      Title: NAT10-mediated mRNA N4-acetylcytidine modification of MDR1 and BCRP promotes breast cancer progression.
    10. N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration.
      Title: N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration.
    Submit: New GeneRIF Correction See all GeneRIFs (53)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag interacts with NAT10 as demonstrated by proximity dependent biotinylation proteomics PubMed
    gag Interaction of HIV-1 Gag with N-acetyltransferase 10 (NAT10) is identified in a series of six affinity purification/mass spectrometry screens PubMed
    Rev rev HIV-1 Rev interacting protein, N-acetyltransferase-like protein (NAT10), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10774, FLJ12179, FLJ23850, KIAA1709, DKFZp434C116

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA polymerase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables N-acetyltransferase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables RNA binding HDA PubMed 
    enables mRNA N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables rRNA cytidine N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA acetylation involved in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA modification TAS
    Traceable Author Statement
    more info
    		  
    involved_in regulation of centrosome duplication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble cytosine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome, telomeric region HDA PubMed 
    located_in membrane HDA PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of telomerase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA cytidine acetyltransferase
    Names
    18S rRNA cytosine acetyltransferase
    N-acetyltransferase 10 (GCN5-related)
    N-acetyltransferase-like protein
    NP_001137502.2
    NP_078938.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051821.2 RefSeqGene

      Range
      5002..46281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144030.2 → NP_001137502.2  RNA cytidine acetyltransferase isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two exons in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform b has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC090469
      Consensus CDS
      CCDS44568.1
      Related
      ENSP00000433011.2, ENST00000531159.6
      Conserved Domains (2) summary
      PLN03229
      Location:828 → 925
      PLN03229; acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
      COG1444
      Location:19 → 829
      TmcA; tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]

    2. NM_024662.3 → NP_078938.3  RNA cytidine acetyltransferase isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC090469
      Consensus CDS
      CCDS7889.1
      UniProtKB/Swiss-Prot
      B4DFD5, E7ESU4, E9PMN9, Q86WK5, Q9C0F4, Q9H0A0, Q9HA61, Q9NVF2
      Related
      ENSP00000257829.3, ENST00000257829.8
      Conserved Domains (2) summary
      PLN03229
      Location:900 → 997
      PLN03229; acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
      COG1444
      Location:20 → 901
      TmcA; tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      34105629..34146908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      34242631..34283911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H0A0.2 GenPept UniProtKB/Swiss-Prot:Q9H0A0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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