U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    FOXJ2 forkhead box J2 [ Homo sapiens (human) ]

    Gene ID: 55810, updated on 18-Sep-2024

    Summary

    Official Symbol
    FOXJ2provided by HGNC
    Official Full Name
    forkhead box J2provided by HGNC
    Primary source
    HGNC:HGNC:24818
    See related
    Ensembl:ENSG00000065970 MIM:619162; AllianceGenome:HGNC:24818
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FHX
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell differentiation; and positive regulation of vascular associated smooth muscle cell proliferation. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in endometrium (RPKM 8.4), ovary (RPKM 8.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FOXJ2 in Genome Data Viewer
    Location:
    12p13.31
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (8032716..8055517)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (8046312..8069122)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (8185312..8208113)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5926 Neighboring gene complement C3a receptor 1 Neighboring gene NANOG hESC enhancer GRCh37_chr12:8229725-8230226 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:8234132-8235331 Neighboring gene NECAP endocytosis associated 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of forkhead box J2 (FOXJ2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    forkhead box protein J2
    Names
    FOXJ2 forkhead factor
    fork head homologous X

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018416.3NP_060886.1  forkhead box protein J2

      See identical proteins and their annotated locations for NP_060886.1

      Status: VALIDATED

      Source sequence(s)
      AC006511, AF155132, AL161978, BC032608, CB243304
      Consensus CDS
      CCDS8587.1
      UniProtKB/Swiss-Prot
      A0AVK4, B2RMP3, Q96PS9, Q9NSN5, Q9P0K8
      Related
      ENSP00000162391.3, ENST00000162391.8
      Conserved Domains (1) summary
      pfam00250
      Location:66143
      Forkhead; Forkhead domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      8032716..8055517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520761.3XP_011519063.1  forkhead box protein J2 isoform X1

      See identical proteins and their annotated locations for XP_011519063.1

      Conserved Domains (1) summary
      pfam00250
      Location:66143
      Forkhead; Forkhead domain
    2. XM_047429152.1XP_047285108.1  forkhead box protein J2 isoform X2

      UniProtKB/Swiss-Prot
      A0AVK4, B2RMP3, Q96PS9, Q9NSN5, Q9P0K8
    3. XM_011520760.3XP_011519062.1  forkhead box protein J2 isoform X1

      See identical proteins and their annotated locations for XP_011519062.1

      Conserved Domains (1) summary
      pfam00250
      Location:66143
      Forkhead; Forkhead domain
    4. XM_017019640.2XP_016875129.1  forkhead box protein J2 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      8046312..8069122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372555.1XP_054228530.1  forkhead box protein J2 isoform X1

    2. XM_054372556.1XP_054228531.1  forkhead box protein J2 isoform X2

      UniProtKB/Swiss-Prot
      A0AVK4, B2RMP3, Q96PS9, Q9NSN5, Q9P0K8
    3. XM_054372554.1XP_054228529.1  forkhead box protein J2 isoform X1

    4. XM_054372557.1XP_054228532.1  forkhead box protein J2 isoform X3