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    Hspbp1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 [ Mus musculus (house mouse) ]

    Gene ID: 66245, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hspbp1provided by MGI
    Official Full Name
    HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1provided by MGI
    Primary source
    MGI:MGI:1913495
    See related
    Ensembl:ENSMUSG00000063802 AllianceGenome:MGI:1913495
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500019G21Rik
    Summary
    Predicted to enable adenyl-nucleotide exchange factor activity; molecular sequestering activity; and ubiquitin protein ligase binding activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and positive regulation of protein ubiquitination. Predicted to be active in endoplasmic reticulum and extracellular space. Is expressed in dentate gyrus subgranular zone. Orthologous to human HSPBP1 (HSPA (Hsp70) binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 24.7), adrenal adult (RPKM 23.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hspbp1 in Genome Data Viewer
    Location:
    7 A1; 7 2.69 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4663514..4688218, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4660515..4685188, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 86B Neighboring gene protein phosphatase 6, regulatory subunit 1 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:4605526-4605679 Neighboring gene STARR-positive B cell enhancer ABC_E3695 Neighboring gene STARR-positive B cell enhancer ABC_E2219 Neighboring gene BR serine/threonine kinase 1 Neighboring gene transmembrane protein 150B Neighboring gene predicted gene, 24537

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis. Rogon C, et al. Mol Biol Cell, 2014 Aug 1. PMID 24899640, Free PMC Article
    2. The Hsc/Hsp70 co-chaperone network controls antigen aggregation and presentation during maturation of professional antigen presenting cells. Kettern N, et al. PLoS One, 2011 Jan 20. PMID 21283720, Free PMC Article
    3. CHIP, a cochaperone/ubiquitin ligase that regulates protein quality control, is required for maximal cardioprotection after myocardial infarction in mice. Zhang C, et al. Am J Physiol Heart Circ Physiol, 2005 Jun. PMID 15665051
    4. Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins. Zhao T, et al. Proc Natl Acad Sci U S A, 2017 Sep 12. PMID 28847953, Free PMC Article
    5. A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability. Koochaki SHJ, et al. J Biol Chem, 2022 Oct. PMID 36108743, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Male HSPBP1knockout mice are sterile because of impaired meiosis and massive apoptosis of spermatocytes.
      Title: HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis.
    2. Provides a critical cardioprotective effect in the setting of ischemia-reperfusion injury due in part to increased apoptosis in cardiac cells.
      Title: CHIP, a cochaperone/ubiquitin ligase that regulates protein quality control, is required for maximal cardioprotection after myocardial infarction in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular sequestering activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular sequestering activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    hsp70-binding protein 1
    Names
    SPA ) binding protein, cytoplasmic cochaperone 1
    heat shock protein-binding protein 1
    hsp70-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360629.1 → NP_001347558.1  hsp70-binding protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC161197
      Consensus CDS
      CCDS20740.1
      UniProtKB/Swiss-Prot
      Q99P31, Q9CYV8
      Conserved Domains (2) summary
      sd00043
      Location:135 → 172
      ARM; armadillo repeat [structural motif]
      pfam08609
      Location:43 → 137
      Fes1; Nucleotide exchange factor Fes1

    2. NM_024172.4 → NP_077134.1  hsp70-binding protein 1

      See identical proteins and their annotated locations for NP_077134.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC161197
      Consensus CDS
      CCDS20740.1
      UniProtKB/Swiss-Prot
      Q99P31, Q9CYV8
      Related
      ENSMUSP00000078886.5, ENSMUST00000079970.6
      Conserved Domains (2) summary
      sd00043
      Location:135 → 172
      ARM; armadillo repeat [structural motif]
      pfam08609
      Location:43 → 137
      Fes1; Nucleotide exchange factor Fes1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      4663514..4688218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242890.2 → XP_030098750.1  hsp70-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q99P31, Q9CYV8
      Conserved Domains (2) summary
      sd00043
      Location:135 → 172
      ARM; armadillo repeat [structural motif]
      pfam08609
      Location:43 → 137
      Fes1; Nucleotide exchange factor Fes1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99P31.1 GenPept UniProtKB/Swiss-Prot:Q99P31

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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