Rbpj recombination signal binding protein for immunoglobulin kappa J region [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rbpjprovided by RGD
Official Full Name: recombination signal binding protein for immunoglobulin kappa J regionprovided by RGD
Primary source: RGD:1593096
See related: EnsemblRapid:ENSRNOG00000046327 AllianceGenome:RGD:1593096
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including negative regulation of smooth muscle cell apoptotic process; negative regulation of smooth muscle cell migration; and positive regulation of smooth muscle cell proliferation. Part of protein-DNA complex. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Orthologous to human RBPJ (recombination signal binding protein for immunoglobulin kappa J region). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Lung (RPKM 138.1), Adrenal (RPKM 103.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q11

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (61551366..61736220, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (57338493..57523330, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (59657738..59865427, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RBPJ promotes hepatic progenitor cell differentiation toward cholangiocytes in vitro and blocks hepatocyte differentiation through mechanisms involving Hippo-Notch crosstalk.
Title: Notch Signaling Coordinates Progenitor Cell-Mediated Biliary Regeneration Following Partial Hepatectomy.

Submit: New GeneRIF Correction

General gene information

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Markers

Rbpj (e-PCR), detects polymorphism
- UniSTS:465468

UniSTS:465469 (e-PCR)
- UniSTS:465469

Rbpj (e-PCR), detects polymorphism
- UniSTS:465469

Rbpsuh-rs3 (e-PCR), detects polymorphism
- UniSTS:166228

X17459 (e-PCR)
- UniSTS:125802

AU026055 (e-PCR)
- UniSTS:114657

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in aortic valve development	ISO Inferred from Sequence Orthology more info
involved_in arterial endothelial cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in atrioventricular canal development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within auditory receptor cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in blood vessel endothelial cell fate specification	ISO Inferred from Sequence Orthology more info
involved_in blood vessel lumenization	ISO Inferred from Sequence Orthology more info
involved_in blood vessel remodeling	ISO Inferred from Sequence Orthology more info
involved_in cardiac left ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell myoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within club cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in dorsal aorta morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endocardium development	ISO Inferred from Sequence Orthology more info
involved_in endocardium morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epidermal cell fate specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition involved in endocardial cushion formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within humoral immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in labyrinthine layer blood vessel development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pituitary gland development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERBB signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell proliferation involved in heart morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription of Notch receptor target	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription of Notch receptor target	ISO Inferred from Sequence Orthology more info
involved_in pulmonary valve development	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion involved in heart morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of generation of precursor metabolites and energy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of timing of cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sebaceous gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within secondary heart field specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somatic stem cell population maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somitogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ventricular trabecula myocardium morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of MAML1-RBP-Jkappa- ICN1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MAML1-RBP-Jkappa- ICN1 complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: recombining binding protein suppressor of hairless

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106631.2 → NP_001100101.1 recombining binding protein suppressor of hairless isoform 1

See identical proteins and their annotated locations for NP_001100101.1

Status: INFERRED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A8I6AFG7, A6IJF7

Related

ENSRNOP00000081140.2, ENSRNOT00000117966.2

Conserved Domains (3) summary

cd01176
Location:315 → 411

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:171 → 293

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:13 → 138

LAG1-DNAbind; LAG1, DNA binding
NM_001414973.1 → NP_001401902.1 recombining binding protein suppressor of hairless isoform 2

Status: INFERRED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

M0R7Q3

Related

ENSRNOP00000093252.2, ENSRNOT00000118409.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

61551366..61736220 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092403.2 → XP_038948331.1 recombining binding protein suppressor of hairless isoform X2

UniProtKB/TrEMBL

A0A8I6AFG7, A0A8I6AN87

Related

ENSRNOP00000095583.1, ENSRNOT00000103399.2

Conserved Domains (3) summary

cd01176
Location:341 → 437

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:197 → 319

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:39 → 164

LAG1-DNAbind; LAG1, DNA binding
XM_039092406.2 → XP_038948334.1 recombining binding protein suppressor of hairless isoform X3

UniProtKB/TrEMBL

A0A8I6AFG7, A0A8I6AL64

Related

ENSRNOP00000093992.1, ENSRNOT00000106059.2

Conserved Domains (3) summary

cd01176
Location:336 → 432

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:192 → 314

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:34 → 159

LAG1-DNAbind; LAG1, DNA binding
XM_039092408.2 → XP_038948336.1 recombining binding protein suppressor of hairless isoform X4

UniProtKB/TrEMBL

A0A8I6AFG7, A6IJF7

Conserved Domains (3) summary

cd01176
Location:315 → 411

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:171 → 293

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:13 → 138

LAG1-DNAbind; LAG1, DNA binding
XM_063273584.1 → XP_063129654.1 recombining binding protein suppressor of hairless isoform X1

UniProtKB/TrEMBL

A0A8I5ZUF4, A6IJF6

Related

ENSRNOP00000109179.1, ENSRNOT00000128294.1
XM_039092405.2 → XP_038948333.1 recombining binding protein suppressor of hairless isoform X3

UniProtKB/TrEMBL

A0A8I6AFG7, A0A8I6AL64

Conserved Domains (3) summary

cd01176
Location:336 → 432

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:192 → 314

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:34 → 159

LAG1-DNAbind; LAG1, DNA binding
XM_039092407.2 → XP_038948335.1 recombining binding protein suppressor of hairless isoform X4

UniProtKB/TrEMBL

A0A8I6AFG7, A6IJF7

Conserved Domains (3) summary

cd01176
Location:315 → 411

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:171 → 293

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:13 → 138

LAG1-DNAbind; LAG1, DNA binding
XM_063273585.1 → XP_063129655.1 recombining binding protein suppressor of hairless isoform X3

UniProtKB/TrEMBL

A0A8I6AL64