Kcnu1 potassium calcium-activated channel subfamily U member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnu1provided by RGD
Official Full Name: potassium calcium-activated channel subfamily U member 1provided by RGD
Primary source: RGD:1585877
See related: EnsemblRapid:ENSRNOG00000014741 AllianceGenome:RGD:1585877
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: rSlo3; KCa5.1
Summary: Predicted to enable potassium channel activity. Predicted to be involved in reproductive process. Predicted to act upstream of or within potassium ion transport and protein stabilization. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Orthologous to human KCNU1 (potassium calcium-activated channel subfamily U member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 78.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.4

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (72844692..72932216, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (66141696..66229493, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (70913825..70998593, complement)

Chromosome 16 - NC_086034.1

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

presence of BKCa channels in the trigeminal nucleus caudalis involved in nociception as is related to migraine
Title: Large conductance calcium-activated potassium channels (BKCa) modulate trigeminovascular nociceptive transmission.
From this study found only a subset of hair cells in the utricle and the crista ampullaris express BK channels. BK-positive hair cells are located mainly in the medial striolar region of the utricle.
Title: Distribution of high-conductance calcium-activated potassium channels in rat vestibular epithelia.
The data support vascular heterogeneity with respect to the activity of BKCa in terms of both beta-subunit regulation and interaction with sarcoplasmic reticulum-mediated Ca2+ signalling
Title: Heterogeneity in function of small artery smooth muscle BKCa: involvement of the beta1-subunit.
BK(Ca) channels are increasingly involved in the control of sensory input in neuropathic pain and may represent a new target for neuropathic pain treatment.
Title: Plasticity and emerging role of BKCa channels in nociceptive control in neuropathic pain.
BK channels, by limiting GABA release from A17s, regulate the flow of excitatory synaptic transmission through the rod pathway.
Title: BK channels modulate pre- and postsynaptic signaling at reciprocal synapses in retina.
Our data indicate a seizure-related down-regulation of BK channels in chronically epileptic rats.
Title: Down-regulation of BK channel expression in the pilocarpine model of temporal lobe epilepsy.
These studies provide concrete morphological evidence for the existence of large-conductance voltage- and calcium-sensitive channels in mitochondria
Title: The calcium-sensitive large-conductance potassium channel (BK/MAXI K) is present in the inner mitochondrial membrane of rat brain.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables large conductance calcium-activated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: potassium channel subfamily U member 1

Names: BK channel; KSper; calcium-activated potassium channel subunit alpha-3; pore-forming subunit of the sperm-specific alkalization activated K(+) current; potassium channel, subfamily U, member 1; slowpoke homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

72844692..72932216 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275979.1 → XP_063132049.1 potassium channel subfamily U member 1 isoform X3

UniProtKB/TrEMBL

A0A8I6AEU3, A6IW00
XM_063275977.1 → XP_063132047.1 potassium channel subfamily U member 1 isoform X1

UniProtKB/TrEMBL

A0A8I6AEU3, A6IW00
XM_063275978.1 → XP_063132048.1 potassium channel subfamily U member 1 isoform X2

UniProtKB/Swiss-Prot

D4A6Z8

UniProtKB/TrEMBL

A0A8I6AEU3, A6IW00

Related

ENSRNOP00000019935.7, ENSRNOT00000019935.9
XM_063275980.1 → XP_063132050.1 potassium channel subfamily U member 1 isoform X4

UniProtKB/TrEMBL

A0A8I6AEU3, A6IW00
XM_063275981.1 → XP_063132051.1 potassium channel subfamily U member 1 isoform X5

UniProtKB/TrEMBL

A0A8I6AEU3, A6IW00
XM_063275982.1 → XP_063132052.1 potassium channel subfamily U member 1 isoform X7
XM_039094935.2 → XP_038950863.1 potassium channel subfamily U member 1 isoform X6

UniProtKB/TrEMBL

A0A8I6AEU3, A6IW00

Conserved Domains (2) summary

pfam00520
Location:104 → 330

Ion_trans; Ion transport protein

pfam03493
Location:472 → 567

BK_channel_a; Calcium-activated BK potassium channel alpha subunit