Eppin epididymal peptidase inhibitor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eppinprovided by RGD
Official Full Name: epididymal peptidase inhibitorprovided by RGD
Primary source: RGD:1597722
See related: EnsemblRapid:ENSRNOG00000028908 AllianceGenome:RGD:1597722
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Wfdc8; Spinlw1
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including negative regulation of calcium ion import; negative regulation of flagellated sperm motility; and negative regulation of peptidase activity. Predicted to be located in acrosomal vesicle and cell surface. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Orthologous to several human genes including EPPIN (epididymal peptidase inhibitor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 78.4), Brain (RPKM 6.7) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (173731739..173738651, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (153312396..153319310, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (161043761..161050550, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data suggested that EPPIN expression in rats is more widespread than in humans and mice, and is androgen-dependent in the epididymis; findings provide new insights into its potential physiological roles in reproduction
Title: Epididymal protease inhibitor (EPPIN) is differentially expressed in the male rat reproductive tract and immunolocalized in maturing spermatozoa.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eppin

Names: WAP four-disulfide core domain protein 8; epididymal protease inhibitor; serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin); serine protease inhibitor-like with Kunitz and WAP domains 1; serine protease inhibitor-like, with Kunitz and WAP domains 1 (eppin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109457.1 → NP_001102927.1 eppin precursor

See identical proteins and their annotated locations for NP_001102927.1

Status: PROVISIONAL

Source sequence(s)

CH474005

UniProtKB/Swiss-Prot

D4A2Z2

Related

ENSRNOP00000019829.5, ENSRNOT00000019829.8

Conserved Domains (2) summary

pfam00014
Location:76 → 127

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam00095
Location:32 → 72

WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'