U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    EcR ecdysone receptor [ Bombyx mori (domestic silkworm) ]

    Gene ID: 692756, updated on 19-Jun-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    EcR
    Gene description
    ecdysone receptor
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bombyx mori
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea; Bombycidae; Bombycinae; Bombyx
    Orthologs
    fruit fly all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See EcR in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_01 current ASM3026992v2 (GCF_030269925.1) 10 NC_085116.1 (6071595..6344745)
    103 previous assembly Bmori_2016v1.0 (GCF_014905235.1) 10 NC_051367.1 (5898025..6171223)

    Chromosome 10 - NC_085116.1Genomic Context describing neighboring genes Neighboring gene telomere-associated protein RIF1 Neighboring gene patched domain-containing protein Neighboring gene microRNA mir-2748 Neighboring gene uncharacterized LOC105842224 Neighboring gene uncharacterized LOC105842223 Neighboring gene uncharacterized LOC134199492 Neighboring gene uncharacterized LOC105842225 Neighboring gene putative fatty acyl-CoA reductase CG5065 Neighboring gene C-type lectin 10

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Morphological changes and patterns of ecdysone receptor B1 immunolocalization in the anterior silk gland undergoing programmed cell death in the silkworm, Bombyx mori. Goncu E, et al. Acta Histochem, 2009. PMID 18554690
    2. Characterization of core promoter elements for ecdysone receptor isoforms of the silkworm, Bombyx mori. Shirai H, et al. Insect Mol Biol, 2007 Apr. PMID 17298552
    3. EcR expression in the prothoracicotropic hormone-producing neurosecretory cells of the Bombyx mori brain. Hossain M, et al. FEBS J, 2006 Aug. PMID 16911531
    4. Tissue-specific and stage-specific expression of two silkworm ecdysone receptor isoforms -- ecdysteroid-dependent transcription in cultured anterior silk glands. Kamimura M, et al. Eur J Biochem, 1997 Sep 15. PMID 9342230
    5. The silkmoth homolog of the Drosophila ecdysone receptor (B1 isoform): cloning and analysis of expression during follicular cell differentiation. Swevers L, et al. Insect Biochem Mol Biol, 1995 Jul. PMID 7633470

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. tyrosine phosphorylated coincidental with high protein tyrosine phosphorylations during growth to differentiation transition
      Title: Ecdysone receptor and ultraspiracle proteins are tyrosine phosphorylated during adult development of silkmoths.
    2. results indicate that EcR-B1 expression may be important for the process of programmed cell death in the anterior silk glands
      Title: Morphological changes and patterns of ecdysone receptor B1 immunolocalization in the anterior silk gland undergoing programmed cell death in the silkworm, Bombyx mori.
    3. downstream promoter element of BmEcR-B1 is not important for BmEcR-A transcription
      Title: Characterization of core promoter elements for ecdysone receptor isoforms of the silkworm, Bombyx mori.
    4. Analysis of EcR-A and EcR-B1 expression during larval-pupal development showed that both genes were up-regulated by 20-hydroxyecdysone in the B. mori brain.
      Title: EcR expression in the prothoracicotropic hormone-producing neurosecretory cells of the Bombyx mori brain.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ecdysone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ecdysone receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ecdysone receptor
    Names
    20-hydroxy-ecdysone receptor
    20E receptor
    ecRH
    ecdysteroid receptor
    nuclear receptor subfamily 1 group H member 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001043866.2 → NP_001037331.2  ecdysone receptor isoform B2

      See identical proteins and their annotated locations for NP_001037331.2

      Status: PROVISIONAL

      Source sequence(s)
      L35266
      UniProtKB/TrEMBL
      A7UBN8
      Conserved Domains (2) summary
      cd06938
      Location:353 → 584
      NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family
      cd07161
      Location:204 → 294
      NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers

    2. NM_001173375.1 → NP_001166846.1  ecdysone receptor isoform B1

      See identical proteins and their annotated locations for NP_001166846.1

      Status: PROVISIONAL

      Source sequence(s)
      L35266
      UniProtKB/Swiss-Prot
      P49881
      UniProtKB/TrEMBL
      A7UBN8
      Conserved Domains (2) summary
      cd06938
      Location:353 → 587
      NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family
      cd07161
      Location:204 → 294
      NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers

    3. NM_001173377.1 → NP_001166848.1  ecdysone receptor isoform A

      Status: PROVISIONAL

      Source sequence(s)
      D49476, D49477
      UniProtKB/TrEMBL
      A0A8R1TG29, A8ASF7
      Conserved Domains (2) summary
      cd07161
      Location:122 → 212
      NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers
      cl11397
      Location:271 → 301
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    RefSeqs of Annotated Genomes: GCF_030269925.1-RS_2024_01

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM3026992v2 Primary Assembly

    Genomic

    1. NC_085116.1 Reference ASM3026992v2 Primary Assembly

      Range
      6071595..6344745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021350704.3 → XP_021206379.1  ecdysone receptor isoform X1

      UniProtKB/TrEMBL
      A0A8R2HNJ9
      Conserved Domains (2) summary
      cd06938
      Location:271 → 505
      NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family
      cd07161
      Location:122 → 212
      NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers

    2. XM_021350703.3 → XP_021206378.1  ecdysone receptor isoform X1

      UniProtKB/TrEMBL
      A0A8R2HNJ9
      Conserved Domains (2) summary
      cd06938
      Location:271 → 505
      NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family
      cd07161
      Location:122 → 212
      NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers

    3. XM_021350705.3 → XP_021206380.1  ecdysone receptor isoform X2

      UniProtKB/TrEMBL
      A0A8R2HQC1
      Conserved Domains (2) summary
      cd06938
      Location:262 → 496
      NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family
      cd07161
      Location:113 → 203
      NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers

    4. XM_062670319.1 → XP_062526303.1  ecdysone receptor isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49881.1 GenPept UniProtKB/Swiss-Prot:P49881

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials